Ain Qurrat-Ul-, Khan Haroon, Mubarak Mohammad S, Pervaiz Aini
Department of Pharmacy, Abdul Wali Khan University Mardan Mardan, Pakistan.
Department of Chemistry, The University of Jordan Amman, Jordan.
Front Pharmacol. 2016 Sep 22;7:292. doi: 10.3389/fphar.2016.00292. eCollection 2016.
An alkaloid is a class of naturally occurring organic nitrogen-containing compounds that are frequently found in the plant kingdom. Many alkaloids are valuable medicinal agents that can be utilized to treat various diseases including malaria, diabetics, cancer, cardiac dysfunction etc. Similarly, platelet aggregation beyond the purpose of homeostasis is the underlying cause of blood clotting related diseases. This review presents a thorough understanding of alkaloids as antiplatelet agents with a possible mechanism of action based on the literature of the last decade. In addition, this review will address the antiplatelet activity of alkaloids and their medicinal usage as potent antiplatelet agents with a description of structural relationship activity and possible lead compounds for future drug discovery.
生物碱是一类天然存在的有机含氮化合物，在植物界中经常被发现。许多生物碱是有价值的药物制剂，可用于治疗各种疾病，包括疟疾、糖尿病、癌症、心脏功能障碍等。同样，超出稳态目的的血小板聚集是与凝血相关疾病的根本原因。本综述基于过去十年的文献，对生物碱作为抗血小板药物及其可能的作用机制进行了全面的了解。此外，本综述将阐述生物碱的抗血小板活性及其作为强效抗血小板药物的药用用途，并描述其构效关系以及未来药物发现可能的先导化合物。
