Chang F R, Chao Y C, Teng C M, Wu Y C
Graduate Institute of Natural Products, Kaohsiung Medical College, Kaohsiung 807, Taiwan, Republic of China.
J Nat Prod. 1998 Jul;61(7):863-6. doi: 10.1021/np970348g.
Using a bioassay-directed fractionation method, three new compounds, including an aporphine alkaloid, cassyformine (4); an oxoaporphine alkaloid, filiformine (8), and a lignan, (+)-diasyringaresinol (10), along with 14 known compounds, were further isolated and characterized from the MeOH extract of the fresh herbs of Cassytha filiformis. Among the isolates of this plant, cathafiline (1), cathaformine (2), actinodaphnine (3), N-methylactinodaphnine (5), predicentrine (6), and ocoteine (7) exhibited significant antiplatelet aggregation activity.
采用生物活性导向的分离方法，从无根藤新鲜全草的甲醇提取物中进一步分离并鉴定出3个新化合物，包括1个阿朴啡生物碱——无根藤碱（4）、1个氧化阿朴啡生物碱——丝状碱（8）和1个木脂素——（+）-二丁香树脂醇（10），以及14个已知化合物。在该植物的分离物中，卡锡非林（1）、卡锡福明（2）、黄肉楠碱（3）、N-甲基黄肉楠碱（5）、前荷叶碱（6）和奥科替宁（7）表现出显著的抗血小板聚集活性。
