Zhang Rongxin, Jiang Meiya, Lei Wenyi, Wang Aoxue
Department of Dermatology, The Second Hospital of Dalian Medical University, Dalian, Liaoning, 116027, People's Republic of China.
Onco Targets Ther. 2021 Feb 10;14:951-957. doi: 10.2147/OTT.S290124. eCollection 2021.
Acanthosis nigricans (AN) is a rare cutaneous condition that may be a manifestation of certain endocrinological or autoimmune diseases, as well as a potential marker for underlying undiagnosed cancer. AN is classified as either benign or malignant based on its clinical associations. Malignant acanthosis nigricans (MAN), which tends to be extensive and develops rapidly, is considered to be a paraneoplastic syndrome associated with advanced cancer, commonly accompanied by intra-abdominal malignancies. Bladder cancer with AN concomitant with tripe palms (TP) and/or mucosal involvement is relatively rare and, to our knowledge, only seven cases of AN with bladder cancer have been reported in the English literature. However, to date, there have been no reports of bladder cancer with AN concomitant with TP, skin and mucosal involvement. Here, we present a case of a 71-year-old male diagnosed with AN coexisting with recurrent bladder cancer and simultaneous TP and oral AN. In addition, we provide a brief review of the available literature on this topic. Early recognition of skin features associated with internal malignancies provides an opportunity for early diagnosis, treatment of the internal malignancy and monitoring of tumor recurrence.
黑棘皮病（AN）是一种罕见的皮肤疾病，可能是某些内分泌或自身免疫性疾病的表现，也是潜在未确诊癌症的一个标志。根据其临床关联，AN可分为良性或恶性。恶性黑棘皮病（MAN）往往范围广泛且发展迅速，被认为是一种与晚期癌症相关的副肿瘤综合征，通常伴有腹内恶性肿瘤。伴有黑棘皮病的膀胱癌同时合并掌跖角化病（TP）和/或黏膜受累相对罕见，据我们所知，英文文献中仅报道了7例伴有膀胱癌的黑棘皮病病例。然而，迄今为止，尚无伴有掌跖角化病、皮肤和黏膜受累的膀胱癌的报道。在此，我们报告一例71岁男性病例，该患者被诊断为患有复发性膀胱癌并同时伴有黑棘皮病和掌跖角化病以及口腔黑棘皮病。此外，我们简要回顾了关于该主题的现有文献。早期识别与内部恶性肿瘤相关的皮肤特征为早期诊断、治疗内部恶性肿瘤以及监测肿瘤复发提供了机会。
