Fabry B, Maksym G N, Butler J P, Glogauer M, Navajas D, Fredberg J J
Physiology Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA.
Phys Rev Lett. 2001 Oct 1;87(14):148102. doi: 10.1103/PhysRevLett.87.148102. Epub 2001 Sep 13.
We report a scaling law that governs both the elastic and frictional properties of a wide variety of living cell types, over a wide range of time scales and under a variety of biological interventions. This scaling identifies these cells as soft glassy materials existing close to a glass transition, and implies that cytoskeletal proteins may regulate cell mechanical properties mainly by modulating the effective noise temperature of the matrix. The practical implications are that the effective noise temperature is an easily quantified measure of the ability of the cytoskeleton to deform, flow, and reorganize.
我们报告了一种标度律，它在广泛的时间尺度范围内以及在各种生物干预下，支配着多种活细胞类型的弹性和摩擦特性。这种标度律将这些细胞识别为接近玻璃化转变的软玻璃材料，并意味着细胞骨架蛋白可能主要通过调节基质的有效噪声温度来调节细胞的力学性能。实际意义在于，有效噪声温度是细胞骨架变形、流动和重组能力的一种易于量化的度量。
