Ginaldi L, Loreto M F, Corsi M P, Modesti M, De Martinis M
Department of Internal Medicine and Public Health, University of L'Aquila, S. Sisto 22/E, 67100, L'Aquila, Italy.
Microbes Infect. 2001 Aug;3(10):851-7. doi: 10.1016/s1286-4579(01)01443-5.
Infectious diseases are major causes, with malignancies, of morbidity and mortality in the elderly. Increased susceptibility to infections may result from underlying dysfunction of an aged immune system; moreover, inappropriate immunologic functions associated with aging can determine an insufficient response to vaccines. Impairments of cellular, humoral and innate immunity in the elderly, contributing to increased incidence of infectious diseases, are discussed in this review.
传染病是老年人发病和死亡的主要原因，与恶性肿瘤一样。对感染易感性增加可能源于衰老免疫系统的潜在功能障碍；此外，与衰老相关的不适当免疫功能可能导致对疫苗的反应不足。本文综述了老年人细胞免疫、体液免疫和先天免疫的损害，这些损害导致传染病发病率增加。
