Wasielewski J A, Holloway F A
Biological Psychology Program, Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Alcohol Res Health. 2001;25(2):94-100.
The complex interaction between alcohol and the body's circadian rhythm has become a rapidly expanding area in chronopharmacology. This area has key implications for the field of alcohol research, because understanding alcohol's effects on the body's internal clock will aid scientists in designing medications and behavioral interventions for treating alcohol abuse and dependence. A number of studies provide evidence that alcohol sensitivity and preference vary with circadian timing. However, only a few studies support alcohol's ability to influence the circadian phase directly. This review focuses on studies examining how alcohol and the body's circadian rhythm interact, using body temperature as an index of circadian rhythm function. Though the research is limited, findings indicate that alcohol sensitivity and preference for drinking to indeed appear to vary with circadian timing and that alcohol may act directly on the central pacemaker to alter circadian functioning.
酒精与人体昼夜节律之间的复杂相互作用已成为时间药理学中一个迅速发展的领域。这一领域对酒精研究领域具有关键意义，因为了解酒精对人体生物钟的影响将有助于科学家设计治疗酒精滥用和依赖的药物及行为干预措施。大量研究表明，酒精敏感性和偏好会随昼夜节律时间而变化。然而，只有少数研究支持酒精直接影响昼夜节律相位的能力。本综述聚焦于以体温作为昼夜节律功能指标，研究酒精与人体昼夜节律如何相互作用的相关研究。尽管研究有限，但结果表明，酒精敏感性和饮酒偏好确实似乎随昼夜节律时间而变化，并且酒精可能直接作用于中央起搏器以改变昼夜节律功能。
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