[植物蜕皮甾体和奈落宝对中毒性肝损伤的药物治疗作用的实验研究]
[Experimental study of pharmacotherapeutic effect of phytoecdisteroids and nerobol in toxic liver damage].
作者信息
Syrov V N, Khushbaktova Z A
机构信息
Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, ul. Kh. Abdulaeva 77, Tashkent, 700170 Uzbekistan.
出版信息
Eksp Klin Farmakol. 2001 Jul-Aug;64(4):56-8.
Phytoecdysteroids ecdysteron and turkesteron isolated from Ajuga turkestanica (Rgl.) Brig. decrease the manifestations of uremic intoxication in rats with experimental renal pathology induced by a nephrotoxic mixture (containing uranyl acetate and glycerol). Injected in a dose of 5 mg/kg, the drugs restore glomerular filtration level, favor the disappearance of the albuminuria and normalize urinary sediments. The nephroprotector effect of the phytoecdysteroids studied resembles the action of a steroidal anabolic drug nerobol.
从突厥筋骨草（Ajuga turkestanica (Rgl.) Brig.）中分离出的植物蜕皮甾酮蜕皮甾酮和土克甾酮可减轻由肾毒性混合物（含醋酸铀酰和甘油）诱导的实验性肾脏病理大鼠的尿毒症中毒表现。以5毫克/千克的剂量注射，这些药物可恢复肾小球滤过水平，有助于蛋白尿消失并使尿沉渣正常化。所研究的植物蜕皮甾酮的肾保护作用类似于甾体同化激素药物奈罗宝的作用。
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