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[植物蜕皮甾类作为实验动物红细胞生成刺激剂的实验研究结果]

[The results of experimental study of phytoecdysteroids as erythropoiesis stimulators in laboratory animals].

作者信息

Syrov V N, Nasyrova S S, Khushbaktova Z A

出版信息

Eksp Klin Farmakol. 1997 May-Jun;60(3):41-4.

PMID:9324397
Abstract

Phytoecdysteroids alpha-ecdysone, 2-desoxyecdysterone, ecdysterone, sileneoside A, and turkesterone isolated from Rhaponticum carthamoides (Willd.) IIjin, Silene brahuica Boiss and Ajuga turkestanica (Rgl.) Repeated administration of brig increased the content of erythrocytes and hemoglobin in the blood of intact rats. The most active of them--ecdysterone, sileneoside A, and, particularly turkesterone, cause also a marked effect on red blood regeneration in hemotoxic phenylhydrazine anemia. In its capacity for simulating erythropoiesis turkesterone resembles the well-known steroidal anabolic drug nerobol.

摘要

从新疆赤芍(Rhaponticum carthamoides (Willd.) IIjin)、须弥蝇子草(Silene brahuica Boiss)和突厥筋骨草(Ajuga turkestanica (Rgl.))中分离出的植物蜕皮甾酮,如α-蜕皮激素、2-脱氧蜕皮甾酮、蜕皮甾酮、蝇子草苷A和土克甾酮。重复给予这些物质可增加正常大鼠血液中红细胞和血红蛋白的含量。其中最具活性的——蜕皮甾酮、蝇子草苷A,尤其是土克甾酮,对苯肼所致血液毒性贫血中的红细胞再生也有显著影响。土克甾酮在模拟红细胞生成方面的能力类似于著名的甾体同化药物尼罗宝。

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1
[The results of experimental study of phytoecdysteroids as erythropoiesis stimulators in laboratory animals].[植物蜕皮甾类作为实验动物红细胞生成刺激剂的实验研究结果]
Eksp Klin Farmakol. 1997 May-Jun;60(3):41-4.
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[Experimental study of pharmacotherapeutic effect of phytoecdisteroids and nerobol in toxic liver damage].[植物蜕皮甾体和奈落宝对中毒性肝损伤的药物治疗作用的实验研究]
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[Comparative study of the effect of ecdysterone, turkesterone and nerobol on the function of rat liver mitochondria in experimental diabetes].[蜕皮甾酮、土牛膝甾酮和 nerobol 对实验性糖尿病大鼠肝脏线粒体功能影响的比较研究]
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[Effect of phytoecdysteroids and nerobol on parameters of carbohydrate and lipid metabolism and phospholipid spectrum of liver mitochondrial membrane in experimental diabetes mellitus of rats].[植物蜕皮甾类和奈落宝对大鼠实验性糖尿病碳水化合物和脂质代谢参数及肝线粒体膜磷脂谱的影响]
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[Action of phytoecdysteroids on the bile-secretory function of the normal liver and in experimental hepatitis].[植物蜕皮甾体对正常肝脏及实验性肝炎胆汁分泌功能的作用]
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Ecdysterone and Turkesterone-Compounds with Prominent Potential in Sport and Healthy Nutrition.表甾酮和土槿皮甲素——运动和健康营养领域具有突出潜力的化合物。
Nutrients. 2024 May 2;16(9):1382. doi: 10.3390/nu16091382.
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[Anabolic activity of phytoecdysone-ecdysterone isolated from Rhaponticum carthamoides (Willd.) Iljin].[从新疆一枝蒿(Rhaponticum carthamoides (Willd.) Iljin)中分离得到的植物蜕皮激素-蜕皮甾酮的合成活性]
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[Effect of phytoecdisteroids and anabolic steroids on liver mitochondrial respiration and oxidative phosphorylation in alloxan diabetic rats].[植物蜕皮甾类和合成代谢类固醇对四氧嘧啶糖尿病大鼠肝脏线粒体呼吸及氧化磷酸化的影响]
Nauchnye Doki Vyss Shkoly Biol Nauki. 1985(9):37-9.

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Biomedicines. 2021 Apr 29;9(5):492. doi: 10.3390/biomedicines9050492.
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Evaluation of Ajuga bracteosa for antioxidant, anti-inflammatory, analgesic, antidepressant and anticoagulant activities.对具苞筋骨草抗氧化、抗炎、镇痛、抗抑郁和抗凝活性的评价。
BMC Complement Altern Med. 2016 Sep 27;16(1):375. doi: 10.1186/s12906-016-1363-y.
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Practical uses for ecdysteroids in mammals including humans: an update.
蜕皮甾类在包括人类在内的哺乳动物中的实际应用:最新进展。
J Insect Sci. 2003;3:7. doi: 10.1093/jis/3.1.7.