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[植物蜕皮甾类作为实验动物红细胞生成刺激剂的实验研究结果]

[The results of experimental study of phytoecdysteroids as erythropoiesis stimulators in laboratory animals].

作者信息

Syrov V N, Nasyrova S S, Khushbaktova Z A

出版信息

Eksp Klin Farmakol. 1997 May-Jun;60(3):41-4.

PMID:9324397
Abstract

Phytoecdysteroids alpha-ecdysone, 2-desoxyecdysterone, ecdysterone, sileneoside A, and turkesterone isolated from Rhaponticum carthamoides (Willd.) IIjin, Silene brahuica Boiss and Ajuga turkestanica (Rgl.) Repeated administration of brig increased the content of erythrocytes and hemoglobin in the blood of intact rats. The most active of them--ecdysterone, sileneoside A, and, particularly turkesterone, cause also a marked effect on red blood regeneration in hemotoxic phenylhydrazine anemia. In its capacity for simulating erythropoiesis turkesterone resembles the well-known steroidal anabolic drug nerobol.

摘要

从新疆赤芍(Rhaponticum carthamoides (Willd.) IIjin)、须弥蝇子草(Silene brahuica Boiss)和突厥筋骨草(Ajuga turkestanica (Rgl.))中分离出的植物蜕皮甾酮,如α-蜕皮激素、2-脱氧蜕皮甾酮、蜕皮甾酮、蝇子草苷A和土克甾酮。重复给予这些物质可增加正常大鼠血液中红细胞和血红蛋白的含量。其中最具活性的——蜕皮甾酮、蝇子草苷A,尤其是土克甾酮,对苯肼所致血液毒性贫血中的红细胞再生也有显著影响。土克甾酮在模拟红细胞生成方面的能力类似于著名的甾体同化药物尼罗宝。

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