Almenar-Queralt A, Goldstein L S
Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0683, USA.
Curr Opin Neurobiol. 2001 Oct;11(5):550-7. doi: 10.1016/s0959-4388(00)00248-8.
The molecular mechanisms that generate efficient and directed transport of proteins and organelles in axons remain poorly understood. In the past year, many studies have identified specific transmembrane or scaffold proteins that might link motor proteins to their cargoes. These studies have also identified previously unsuspected pathways and raised the intriguing possibility that pre-packaged groups of functionally related proteins are transported together in the axon. Evidence suggests that fast molecular motor proteins have a role in slow axonal transport, and the axonal transport machinery has been implicated in the genesis of neurodegenerative diseases.
在轴突中产生蛋白质和细胞器高效定向运输的分子机制仍未得到充分理解。在过去的一年里，许多研究已经确定了可能将运动蛋白与其货物连接起来的特定跨膜或支架蛋白。这些研究还发现了以前未被怀疑的途径，并提出了一个有趣的可能性，即功能相关的蛋白质预包装组在轴突中一起运输。有证据表明，快速分子运动蛋白在慢速轴突运输中起作用，并且轴突运输机制与神经退行性疾病的发生有关。
