水杨酸钠与万古霉素联合根除形成生物膜的表皮葡萄球菌（RP62A）
Eradication of biofilm-forming Staphylococcus epidermidis (RP62A) by a combination of sodium salicylate and vancomycin.
作者信息
Polonio R E, Mermel L A, Paquette G E, Sperry J F
机构信息
Department of Biochemistry, Microbiology and Molecular Genetics, University of Rhode Island, Kingston, Rhode Island 02881, USA.
出版信息
Antimicrob Agents Chemother. 2001 Nov;45(11):3262-6. doi: 10.1128/AAC.45.11.3262-3266.2001.
Abstract
Staphylococcus epidermidis is a major cause of infections associated with indwelling medical devices. Biofilm production is an important virulence attribute in the pathogenesis of device-related infections. Therefore, elimination of these biofilms is an ideal treatment. Salicylate (5 mM) combined with 1 microg of vancomycin per ml inhibited biofilm formation by S. epidermidis (RP62A) by >or=99.9%. When biofilm-coated polystyrene beads were exposed to 5 mM sodium salicylate and 4 microg of vancomycin per ml (one-half the minimum biofilm eradication concentration), there was a >99.9% reduction in viable count.
摘要
表皮葡萄球菌是与植入式医疗器械相关感染的主要原因。生物膜形成是器械相关感染发病机制中的一个重要毒力属性。因此，消除这些生物膜是一种理想的治疗方法。水杨酸盐（5 mM）与每毫升1微克万古霉素联合使用可抑制表皮葡萄球菌（RP62A）形成生物膜，抑制率≥99.9%。当生物膜包被的聚苯乙烯珠暴露于5 mM水杨酸钠和每毫升4微克万古霉素（最低生物膜根除浓度的一半）时，活菌数减少>99.9%。
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