Grennan D M, Zeitlin I J, Mitchell W S, Buchanan W W, Dick W C
Prostaglandins. 1975 May;9(5):799-816. doi: 10.1016/0090-6980(75)90115-x.
In these experiments we have examined the effects of PGE1, PGE2, PGF1alpha and PGF2alpha on synovial perfusion in the normal canine synovial microcirculation. The effects of the drugs on synovial perfusion were determined indirectly from the changes produced in the rate of clearance of 133Xenon from the joint by their intra-articular injection. Prostaglandins PGE1 and PGE2 were found to be strongly vasodilator with PGE1 being the more active. PGF1alpha appeared to have little or no vasoactive properties in doses up to 1 ugm. (2.8 times 10(-5M)) in our preparation while PGF2alpha was vasodilator at this high dosage only. Neither SC19920 nor diphloretin phosphate antagonished the effects of PGE1 in these experiments.
在这些实验中，我们研究了前列腺素E1、前列腺素E2、前列腺素F1α和前列腺素F2α对正常犬滑膜微循环中滑膜灌注的影响。通过关节内注射这些药物后，根据133氙从关节清除速率的变化间接确定药物对滑膜灌注的影响。发现前列腺素E1和前列腺素E2具有强烈的血管舒张作用，其中前列腺素E1更为活跃。在我们的实验制剂中，剂量高达1微克（2.8×10⁻⁵摩尔）时，前列腺素F1α似乎几乎没有血管活性，而前列腺素F2α仅在这个高剂量时具有血管舒张作用。在这些实验中，SC19920和二氢黄酮磷酸酯均未拮抗前列腺素E1的作用。
