正在戒毒的吸毒者的血清维生素E、C和A水平：吸毒习惯、性行为及生活方式因素的影响

Serum vitamin E, C and A status of the drug addicts undergoing detoxification: influence of drug habit, sexual practice and lifestyle factors.

作者信息

Nazrul Islam S K, Jahangir Hossain K, Ahsan M

机构信息

Institute of Nutrition and Food Science, University of Dhaka, Dhaka-1000, Bangladesh.

出版信息

Eur J Clin Nutr. 2001 Nov;55(11):1022-7. doi: 10.1038/sj.ejcn.1601263.

DOI:10.1038/sj.ejcn.1601263

PMID:11641753

Abstract

BACKGROUND

The study was carried out on the hypothesis that drug addicts would have reduced vitamin E, C and A status which could be influenced by drug habit, sexual practice and lifestyle factors.

METHOD

Serum concentrations of Vitamin E, C and A of male drug addicts and cohort controls were analysed, and influence of drug habit, sexual practice and lifestyle factors of the addicts on the vitamin status was assessed. The study was conducted among 253 drug addicts who sought detoxification voluntarily during the period of June 1997 to July 1998 at the Central Drug Addiction Treatment Hospital, Dhaka, and 100 cohort control men. Research instruments were questionnaire and blood specimens. HPLC and spectrophotometric methods were used to determine the vitamin levels in sera of drug addicts.

RESULTS

alpha-Tocopherol (12.60+/-3.73 compared with 16.3+/-3.37 micromol/l; t=8.6, P=0.05), ascorbic acid (21.59+/-10.5 compared with 38.3+/-13.62 micromol/l; t=10.93, P=0.003) and retinol (1.15+/-0.39 compared with 1.33+/-0.30 micromol/l; t=5.28, P=0.048) in the drug addicts were significantly low as compared to those in the cohort controls. Use of multiple illicit drugs for a longer period of time did result in reduced levels of these vitamins. A significant reduction in retinol concentration was noted among the multiple drug users (F(2,250)=3.23, P=0.041). Duration of addiction had a significant linear correlation with the level of reduction in retinol (F(2,250)=3.23, P=0.041) and alpha-tocopherol (F(2,250)=3.06, P=0.049). Apart from having a significant negative correlation between number of sexual partners and retinol level (F(3,247)=2.65, P=0.049), sexual practice did not have any influence on the vitamin status of the addicts. Occupation did have a significant effect on the ascorbic acid level (F(4,248)=2.46, P=0.046), but other socioeconomic factors like income, age etc did not influence the vitamin E, C and A levels. Body mass index had a positive linear correlation with the vitamins, but it was significant only with vitamin C (F(2,250)=7.06, P=0.001).

CONCLUSIONS

These results could have important implications for providing an antioxidant therapy to drug addicts and thus rehabilitating them into normal life. Risk of HIV infection and transmission (if any) could be reduced or inhibited.

摘要

背景

本研究基于这样的假设开展，即吸毒者体内维生素E、C和A水平会降低，且这些指标会受到吸毒习惯、性行为及生活方式因素的影响。

方法

分析男性吸毒者及队列对照者血清中维生素E、C和A的浓度，并评估吸毒者的吸毒习惯、性行为及生活方式因素对维生素水平的影响。研究对象为1997年6月至1998年7月期间在达卡中央戒毒治疗医院自愿寻求戒毒治疗的253名吸毒者以及100名队列对照男性。研究工具包括问卷和血液样本。采用高效液相色谱法（HPLC）和分光光度法测定吸毒者血清中的维生素水平。

结果

与队列对照者相比，吸毒者的α-生育酚（12.60±3.73 vs 16.3±3.37微摩尔/升；t = 8.6，P = 0.05）、抗坏血酸（21.59±10.5 vs 38.3±13.62微摩尔/升；t = 10.93，P = 0.003）和视黄醇（1.15±0.39 vs 1.33±0.30微摩尔/升；t = 5.28，P = 0.048）水平显著降低。长期使用多种非法药物确实会导致这些维生素水平降低。在多种药物使用者中，视黄醇浓度显著降低（F(2,250)=3.23，P = 0.041）。成瘾持续时间与视黄醇（F(2,250)=3.23，P = 0.041）和α-生育酚（F(2,250)=3.06，P = 0.049）水平的降低呈显著线性相关。除性伴侣数量与视黄醇水平之间存在显著负相关（F(3,247)=2.65，P = 0.049）外，性行为对吸毒者的维生素状态没有任何影响。职业对视黄醇水平有显著影响（F(4,248)=2.46，P = 0.046），但收入、年龄等其他社会经济因素对维生素E、C和A水平没有影响。体重指数与这些维生素呈正线性相关，但仅与维生素C显著相关（F(2,250)=7.06，P = 0.001）。