Löffler H, Lück R, Ali S S
Dtsch Med Wochenschr. 1975 Oct 10;100(41):2092-8. doi: 10.1055/s-0028-1106506.
Eosinophilic leukaemia was diagnosed in a 13-year-old boy with clinical and haematological signs of acute leukaemia. A positive naphthol-AS-D-chloroacetate esterase reaction was present in 93% of bone marrow eosinophils. This confirms earlier findings for this sub-group of leukaemia in adultsmcharcot-Leyden's crystals were found in bone marrow, and the eosinophils were further characterized by other cytochemical and electronmicroscopic studies. Only short remission periods were achieved, the patient dying 53 weeks after diagnosis. Attacks of cardiac arrhythmias, thought to be due to adriamycin treatment, were probably related to thrombi in the coronary arteries as a result of disseminated intravascular coagulation. It is thought that eosinophilic leukaemia with a positive naphthol-AS-D-chloroacetate esterase reaction is a variant of acute myeloid leukaemia.
一名13岁男孩被诊断为嗜酸性粒细胞白血病，伴有急性白血病的临床和血液学体征。93%的骨髓嗜酸性粒细胞中存在萘酚-AS-D-氯乙酸酯酶反应阳性。这证实了成人白血病这一亚组的早期研究结果，在骨髓中发现了夏科-莱登结晶，并通过其他细胞化学和电子显微镜研究对嗜酸性粒细胞进行了进一步表征。仅获得了短暂的缓解期，患者在诊断后53周死亡。被认为是由阿霉素治疗引起的心律失常发作，可能与弥散性血管内凝血导致的冠状动脉血栓有关。据认为，萘酚-AS-D-氯乙酸酯酶反应阳性的嗜酸性粒细胞白血病是急性髓细胞白血病的一种变体。
