腺病毒2型DNA复制。II. DNA复制的末端
Adenovirus type 2 DNA replication. II. Termini of DNA replication.
作者信息
Schilling R, Weingärtner B, Winnacker E L
出版信息
J Virol. 1975 Oct;16(4):767-74. doi: 10.1128/JVI.16.4.767-774.1975.
Abstract
Complete, mature adenovirus type 2 DNA molecules were isolated from virus-infected HeLa cells, pulse-labeled at 20 h postinfection in [3H]thymidine pulses shorter than the time necessary for one round of viral DNA replication. After digestion with the restriction endonucleases Eco RI, Hpa I, and Hind III, a temporal order of synthesis of different regions of the viral genome was established from the relative specific radioactivities in the restriction enzyme fragments. A comparison with the physical order of these fragments revealed the existence of two termini of DNA replication towards both the molecular right and left ends, respectively, of the viral chromosome.
摘要
从病毒感染的HeLa细胞中分离出完整、成熟的2型腺病毒DNA分子，在感染后20小时用[3H]胸苷进行脉冲标记，脉冲时间短于一轮病毒DNA复制所需的时间。用限制性内切酶Eco RI、Hpa I和Hind III消化后，根据限制性酶切片段中的相对比放射性确定了病毒基因组不同区域的合成时间顺序。将这些片段的物理顺序进行比较，发现分别朝着病毒染色体分子右端和左端存在两个DNA复制末端。
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