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婴儿肠炎病毒：形态发生与形态学

Infantile enteritis viruses: morphogenesis and morphology.

出版信息

J Virol. 1975 Oct;16(4):937-43. doi: 10.1128/JVI.16.4.937-943.1975.

DOI:10.1128/JVI.16.4.937-943.1975
PMID:1165598
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC354755/
Abstract

A new virus was found to be associated with acute gastroenteritis in children. In duodenal biopsies, it was observed infecting only intestinal epithelial cells, and it resembled orbiviruses in its morphogenesis. For diagnsotic purposes the virus was readily demonstrated by negative staining of fecal extracts. Two forms of particles were seen: double-sheeled particles (70 to 75 nm in diameter) resembling those of reovirus with a sharper outline, and single-shelled particles (60 nm in diameter) with obvious capsomer structure and resembling those of orbiviruses. The morphological resemblance of this human virus to the viruses of "Nebraska" calf scours and epizootic diarrhoea of infant mice is emphasized.

摘要

一种新病毒被发现与儿童急性肠胃炎有关。在十二指肠活检中，观察到该病毒仅感染肠道上皮细胞，并且在形态发生方面类似于环状病毒。为了诊断目的，通过粪便提取物的负染色很容易证明该病毒的存在。观察到两种形式的颗粒：直径70至75纳米的双层颗粒，其轮廓比呼肠孤病毒的颗粒更清晰，类似于呼肠孤病毒；以及直径60纳米的单层颗粒，具有明显的壳粒结构，类似于环状病毒。强调了这种人类病毒与“内布拉斯加”犊牛腹泻病毒和幼鼠流行性腹泻病毒在形态上的相似性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/696ded7b3da3/jvirol00238-0194-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/80218aa4fcf5/jvirol00238-0190-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/7bfeb5e0203a/jvirol00238-0191-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/0075e09da02b/jvirol00238-0191-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/a769c4275a25/jvirol00238-0191-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/60c20d2a5857/jvirol00238-0192-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/badcfe48a063/jvirol00238-0193-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/75d247520dbb/jvirol00238-0193-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/2be5caf4829f/jvirol00238-0193-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/696ded7b3da3/jvirol00238-0194-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/80218aa4fcf5/jvirol00238-0190-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/7bfeb5e0203a/jvirol00238-0191-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/0075e09da02b/jvirol00238-0191-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/a769c4275a25/jvirol00238-0191-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/60c20d2a5857/jvirol00238-0192-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/badcfe48a063/jvirol00238-0193-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/75d247520dbb/jvirol00238-0193-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/2be5caf4829f/jvirol00238-0193-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/354755/696ded7b3da3/jvirol00238-0194-a.jpg

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本文引用的文献

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Electron-Microscopic Study of the Intestinal Epithelium of Mice Infected with the Agent of Epizootic Diarrhea of Infant Mice (EDIM Virus).感染幼鼠流行性腹泻病原体（EDIM病毒）的小鼠肠道上皮的电子显微镜研究
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马拉维儿童环境肠道功能障碍患儿的生长速度与胃肠道特定细菌和病毒分类群有关。
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