Novak E R, Lambrou C D, Woodruff J D
Obstet Gynecol. 1975 Oct;46(4):401-6.
Among the 2300 cases accumulated in the Emil Novak Tumor Registry between the years 1942 and 1972, there were 100 examples of ovarian neoplasia associated with gestation. Lutein cysts or luteomas were excluded since such lesions usually represent physiologic responses of the gonad to increased levels of chorionic gonadotropin. Only 10 cases of dermoids (benign cystic teratomas) were reviewed. We believe this to be the largest series reported in conjunction with pregnancy. There was a total 5-year salvage rate of 76%, which is obviously much greater than with ovarian tumors in general, although there are certain patients alive with a late recurrence. This excellent survival rate seemingly reflects the low-grade malignant potential of many of the neoplasms encountered during pregnancy. However, certain cases of extremely aggressive and advanced ovarian tumors as noted at operation seemed to do surprisingly well following termination of pregnancy, and one must speculate whether gestation impairs antibody response with an apparent immunologic rebound postpartum.
在1942年至1972年间埃米尔·诺瓦克肿瘤登记处积累的2300例病例中，有100例卵巢肿瘤与妊娠相关。黄体囊肿或黄体瘤被排除在外，因为此类病变通常代表性腺对绒毛膜促性腺激素水平升高的生理反应。仅对10例皮样囊肿（良性囊性畸胎瘤）进行了回顾。我们认为这是与妊娠相关报道中规模最大的系列病例。总的5年挽救率为76%，这显然远高于一般卵巢肿瘤，尽管有某些患者出现晚期复发后仍存活。这种出色的生存率似乎反映了妊娠期间所遇到的许多肿瘤的低恶性潜能。然而，手术中发现的某些极具侵袭性且晚期的卵巢肿瘤病例在妊娠终止后似乎恢复得惊人地好，人们不禁推测妊娠是否会损害抗体反应并在产后出现明显的免疫反弹。
