顶体指数并非传统体外受精和卵胞浆内单精子注射后结局的绝对预测指标。
Acrosome index is not an absolute predictor of the outcome following conventional in vitro fertilization and intracytoplasmic sperm injection.
作者信息
Söderlund B, Lundin K
机构信息
Department of Obstetrics and Gynaecology, Göteborg University, SU/Sahlgrenska, SE 413 45 Göteborg, Sweden.
出版信息
J Assist Reprod Genet. 2001 Sep;18(9):483-9. doi: 10.1023/a:1016696909515.
PURPOSE
To investigate if including evaluation of acrosome index (AI) in the semen analysis of teratozoospermic samples could help to predict for which patients intracytoplasmic sperm injection (ICSI) is necessary.
METHODS
The fertilization rate, pregnancy rate, and percentage of good quality embryos were compared after performing conventional in vitro fertilization (IVF) and ICSI, respectively, using sibling oocytes. The role of AI was evaluated by dividing patients into two groups; Group A (AI < 7%) and Group B (AI > or = 7%).
RESULTS
A significant difference in fertilization rate was observed between Group A and B after conventional IVF. In Group A, the fertilization rate, embryo transfer rate, and percentage of good quality embryos were higher after ICSI than after IVF. In Group B, the fertilization and pregnancy rates were numerically but not significantly higher after IVF compared to ICSI.
CONCLUSION
Evaluation of acrosome index will not accurately predict fertilization, although this study shows that a sperm sample with less than 5% normal forms and an AI greater than 7% may achieve a mean fertilization rate > 70% after conventional IVF.
目的
探讨在畸形精子症样本的精液分析中纳入顶体指数（AI）评估是否有助于预测哪些患者需要进行卵胞浆内单精子注射（ICSI）。
方法
分别使用姐妹卵母细胞进行常规体外受精（IVF）和ICSI后，比较受精率、妊娠率和优质胚胎百分比。通过将患者分为两组来评估AI的作用；A组（AI<7%）和B组（AI≥7%）。
结果
常规IVF后，A组和B组的受精率存在显著差异。在A组中，ICSI后的受精率、胚胎移植率和优质胚胎百分比高于IVF后。在B组中，与ICSI相比，IVF后的受精率和妊娠率在数值上较高，但无显著差异。
结论
顶体指数评估不能准确预测受精情况，尽管本研究表明，正常形态少于5%且AI大于7%的精子样本在常规IVF后可能实现平均受精率>70%。
Zotero 插件