Kyriaki M, Eleni T, Efi P, Ourania K, Vassilios S, Lambros V
Pain Relief and Palliative Care Unit, University of Athens, Areteion Hospital, 76 Vas. Sofias Ave., Athens 11528, Greece.
Int J Cancer. 2001 Oct 1;94(1):135-9. doi: 10.1002/ijc.1439.
In 1986, the European Organization for Research and Treatment (EORTC) initiated a research program to develop an integrated, modular approach for evaluating the quality of life of patients participating in international clinical trials. The questionnaire was designed to measure cancer patients' physical, psychological and social functions. The questionnaire is composed of 5 multiitem scales (physical, role, social, emotional and cognitive functioning) and 9 single items (pain, fatigue, financial impact, appetite loss, nausea/vomiting, diarrhea, constipation, sleep disturbance and quality of life). It was administered to the patients before the initiation of palliative treatment and then once again during the treatment. The validation of the questionnaire took place at Areteion Hospital, while the translation was conducted by the EORTC bureau. The final validation sample consisted of 120 cancer patients. The clinical variable assessed was the performance status. The aim of our study was to assess the applicability of this quality of life measurement on a Hellenic sample of cancer patients receiving palliative care. The results showed that the questionnaire was well accepted in the present patient population. In addition, the questionnaire was found to be useful in detecting the effectiveness of palliative treatment over time. The scale reliability was very good (pretreatment from 0.57-0.79, ontreatment from 0.56-0.75), especially for the functioning scale. In addition, very good validity was found in all the approaches used. Moreover, the factor analysis results in a 6-factor solution that satisfies the criteria of reproducibility, interpretability and confirmatory setting. Performance status showed an improvement (p < 0.0025) during the studied period. These results support that the QLQ-C30 (version 3.0) has proven to be a reliable and valid measure of the quality of life in Greek cancer patients receiving palliative care treatment.
1986年，欧洲癌症研究与治疗组织（EORTC）启动了一项研究计划，旨在开发一种综合、模块化的方法来评估参与国际临床试验患者的生活质量。该问卷旨在测量癌症患者的身体、心理和社会功能。问卷由5个多项目量表（身体、角色、社会、情感和认知功能）和9个单项（疼痛、疲劳、经济影响、食欲减退、恶心/呕吐、腹泻、便秘、睡眠障碍和生活质量）组成。在姑息治疗开始前对患者进行问卷调查，然后在治疗期间再次进行调查。问卷在阿雷泰翁医院进行了效度验证，翻译工作由EORTC办事处完成。最终的效度验证样本包括120名癌症患者。评估的临床变量是体能状态。我们研究的目的是评估这种生活质量测量方法在接受姑息治疗的希腊癌症患者样本中的适用性。结果表明，该问卷在当前患者群体中得到了很好的接受。此外，还发现该问卷有助于检测姑息治疗随时间的有效性。量表信度非常好（治疗前为0.57 - 0.79，治疗中为0.56 - 0.75），尤其是功能量表。此外，在所有使用的方法中都发现了很好的效度。而且，因子分析结果得到了一个6因子解决方案，满足可重复性、可解释性和验证性设置的标准。在研究期间，体能状态有所改善（p < 0.0025）。这些结果支持QLQ - C30（第3.0版）已被证明是评估接受姑息治疗的希腊癌症患者生活质量的可靠且有效的指标。
