Zhang Lei, Wang Ning, Zhang Jing, Liu Jiahao, Luo Zhiqin, Sun Weilin, Woo Stephanie Mu-Lian, Chen Chujun, Zhang Kai, Miller Adam R, Guo Hui, Zhang Xueying, Wang Changli
Department of Thoracic Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Lung Cancer Center, Tianjin, People's Republic of China.
Xiangya Medical School, Central South University, Changsha, People's Republic of China.
Palliat Med. 2016 Apr;30(4):401-8. doi: 10.1177/0269216315593671. Epub 2015 Jun 29.
Simplified by European Organization for Research and Treatment of Cancer (EORTC) Quality-of-Life Questionnaire Core 30 (QLQ-C30), EORTC Quality-of-Life Questionnaire Core 15 Palliative Care (QLQ-C15-PAL) is specifically applied to evaluating palliative care patients' quality of life.
This study examined cross-cultural adaptability and validity of QLQ-C15-PAL for evaluating quality of life of palliative care patients with advanced cancer in mainland China.
From May to October 2013, 243 palliative care patients in Tianjin Cancer Hospital completed the EORTC QLQ-C30. We extracted QLQ-C15-PAL data for analysis. Physicians completed the Eastern Cooperative Oncology Group Performance Status score and mental state assessment for each patient.
A total of 243 patients completed the study. The compliance rate was high, with missing rate for each item ranging from 0% to 2.1%. In addition to emotional function, the remaining dimensions demonstrated a high reliability (Cronbach's alpha > 0.7). Whether we divided patients into two groups according to their Eastern Cooperative Oncology Group Performance Status or divided patients into three groups according to mental status, both sets of results showed significant differences in QLQ-C15-PAL subscale scores (p < 0.05), indicating that the QLQ-C15-PAL scale could be used to distinguish between the aforementioned subgroups. Overall quality of life was moderately correlated with fatigue (r = -0.406) but weakly correlated with other subscales. The proportion of variance (R(2)) ranged from 0.848 to 0.903, which showed that QLQ-C15-PAL subscale scores explained between 84.8% and 90.3% of the original QLQ-C30 score distribution.
The Chinese version of the EORTC QLQ-C15-PAL questionnaire has high reliability and validity and is therefore suitable for clinical use in China to determine health-related quality of life in Chinese patients with advanced cancer.
欧洲癌症研究与治疗组织生活质量问卷核心30项（QLQ-C30）简化版的欧洲癌症研究与治疗组织生活质量问卷姑息治疗核心15项（QLQ-C15-PAL）专门用于评估姑息治疗患者的生活质量。
本研究考察QLQ-C15-PAL在中国大陆晚期癌症姑息治疗患者生活质量评估中的跨文化适应性和有效性。
2013年5月至10月，天津医科大学肿瘤医院的243例姑息治疗患者完成了欧洲癌症研究与治疗组织生活质量问卷核心30项（QLQ-C30）。我们提取了QLQ-C15-PAL数据进行分析。医生完成了东部肿瘤协作组体能状态评分和每位患者的精神状态评估。
共有243例患者完成研究。依从率较高，各项目的缺失率在0%至2.1%之间。除情感功能外，其余维度显示出较高的信度（Cronbach's α>0.7）。无论我们根据东部肿瘤协作组体能状态将患者分为两组，还是根据精神状态将患者分为三组，两组结果均显示QLQ-C15-PAL分量表得分存在显著差异（p<0.05），表明QLQ-C15-PAL量表可用于区分上述亚组。总体生活质量与疲劳呈中度相关（r=-0.406），但与其他分量表呈弱相关。方差比例（R²）在0.848至0.903之间，这表明QLQ-C15-PAL分量表得分解释了原始QLQ-C30得分分布的84.8%至90.3%。
欧洲癌症研究与治疗组织QLQ-C15-PAL问卷中文版具有较高的信度和效度，因此适合在中国临床使用，以确定中国晚期癌症患者的健康相关生活质量。
