Katano K, Kawano M, Koni I, Sugai S, Muro Y
Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
J Rheumatol. 2001 Oct;28(10):2238-44.
To determine whether the clinical and laboratory characteristics of anticentromere antibody (ACA) positive, anti-SSA/Ro antibody (SSA) negative primary Sjogren's syndrome (SS) differ from SSA positive, ACA negative primary SS.
Twelve patients with ACA positive primary SS (ACA SS) and 19 patients with SSA positive primary SS (SSA SS) were examined. We compared the age, laboratory data, proportion with Raynaud's phenomenon (RP), activity of natural killer cells (NK), titer of antibodies against Epstein-Barr virus, and histological findings of minor labial salivary glands. The presence of anti-chromo antibodies (AChA) was evaluated by immunoblotting of patients' sera.
The mean age of the ACA SS group was higher than that of the SSA SS group (p < 0.05). Serum IgG level was lower in ACA SS than in SSA SS (p < 0.0001). Serum IgG level of the ACA SS group with one exception was close to the normal range. Leukocytopenia was less frequently observed in ACA SS than in SSA SS (p < 0.05). RP was seen more frequently in the ACA SS group than the SSA SS group (p < 0.05). NK activity of the ACA SS group was higher than that of the SSA SS group (p < 0.05). Most of the ACA SS patients' NK activity was normal, in contrast to the tendency for NK activity in SS to be low. Virus capsid antigen IgA titer of the ACA SS group was lower than that of the SSA SS group (p < 0.05). Histological findings of minor labial salivary glands of both groups showed a similar severity of lymphocytic infiltrates, destruction of normal structures, and pattern of infiltrating lymphocyte subsets. AChA was positive in 11 of the 12 sera of ACA SS patients.
The results confirm that ACA positive primary SS differs from SSA positive classic SS in several significant respects.
确定抗着丝点抗体（ACA）阳性、抗SSA/Ro抗体（SSA）阴性的原发性干燥综合征（SS）的临床和实验室特征是否与SSA阳性、ACA阴性的原发性SS不同。
检查了12例ACA阳性原发性SS（ACA SS）患者和19例SSA阳性原发性SS（SSA SS）患者。我们比较了年龄、实验室数据、雷诺现象（RP）的比例、自然杀伤细胞（NK）活性、抗Epstein-Barr病毒抗体滴度以及小唇唾液腺的组织学表现。通过对患者血清进行免疫印迹评估抗染色体抗体（AChA）的存在情况。
ACA SS组的平均年龄高于SSA SS组（p < 0.05）。ACA SS组的血清IgG水平低于SSA SS组（p < 0.0001）。除1例患者外，ACA SS组的血清IgG水平接近正常范围。ACA SS组白细胞减少的发生率低于SSA SS组（p < 0.05）。ACA SS组中RP的发生率高于SSA SS组（p < 0.05）。ACA SS组的NK活性高于SSA SS组（p < 0.05）。与SS患者NK活性往往较低的趋势相反，大多数ACA SS患者的NK活性正常。ACA SS组的病毒衣壳抗原IgA滴度低于SSA SS组（p < 0.05）。两组小唇唾液腺的组织学表现显示淋巴细胞浸润的严重程度、正常结构的破坏以及浸润淋巴细胞亚群的模式相似。12例ACA SS患者血清中有11例AChA呈阳性。
