Castella A, Joshi S, Raaschou T, Mason N
Faculty of Medicine, Pathology Department, UAE University, Al Ain, United Arab Emirates.
Acta Oncol. 2001;40(5):660-4. doi: 10.1080/028418601750444231.
The aim of this study was to analyze the distribution of the various pathologic types of lymphoma in a native Arab population of the United Arab Emirates (UAE). Two hundred and eight patients with malignant lymphoma diagnosed over a 12-year period (1988-1999) were retrospectively studied morphologically and immunohistochemically with a panel of monoclonal antibodies and classified according to the revised European-American classification of lymphoid neoplasms (REAL). Of the 208 patients in the study, 41% had Hodgkin's disease (HD) and 59% had non-Hodgkin's lymphoma (NHL). The distribution of HD showed a predominance of nodular sclerosis and mixed cellularity types. Among NHLs, the most frequent type was diffuse large B cell (59% of all NHLs) followed by the Burkitt's type (13%). The proportion of primary extranodal NHL was 29%. Immunologically, the percentages of NHL with B-cell and T-cell phenotypes were 83 and 11, respectively. When the International Working Formulation was used, 34% of NHLs were classified as high grade, 59% as intermediate grade and only 7% as low-grade lymphomas.
本研究旨在分析阿拉伯联合酋长国（UAE）当地阿拉伯人群中淋巴瘤各种病理类型的分布情况。对1988年至1999年这12年间诊断出的208例恶性淋巴瘤患者进行回顾性研究，采用一组单克隆抗体进行形态学和免疫组织化学分析，并根据修订后的欧美淋巴样肿瘤分类（REAL）进行分类。在该研究的208例患者中，41%患有霍奇金病（HD），59%患有非霍奇金淋巴瘤（NHL）。HD的分布显示结节硬化型和混合细胞型占主导。在NHL中，最常见的类型是弥漫性大B细胞型（占所有NHL的59%），其次是伯基特型（13%）。原发性结外NHL的比例为29%。从免疫学角度来看，具有B细胞和T细胞表型的NHL百分比分别为83%和11%。当采用国际工作分类法时，34%的NHL被归类为高级别，59%为中级别，只有7%为低级别淋巴瘤。
