单剂量环丙沙星治疗男性淋病感染
Single dose ciprofloxacin for treating gonococcal infections in men.
作者信息
Loo P S, Ridgway G L, Oriel J D
出版信息
Genitourin Med. 1985 Oct;61(5):302-5. doi: 10.1136/sti.61.5.302.
Abstract
A single oral dose of ciprofloxacin 500 mg was used to treat five men with gonococcal urethritis and five men with gonococcal proctitis, and all were cured. In a subsequent study the dose of ciprofloxacin was reduced to 250 mg, and 54 men with 57 gonococcal infections (47 urethral, seven rectal, and three pharyngeal) were treated; of the isolates of Neisseria gonorrhoeae, four were penicillinase producing strains. All the patients were cured of gonococcal infection. Urethral specimens from nine of the men with gonococcal urethritis yielded Chlamydia trachomatis before treatment. These organisms were isolated again from all these patients seven days after treatment, and from a further seven men who had been chlamydia negative before treatment. It is concluded that a single oral dose of ciprofloxacin is an effective treatment for uncomplicated gonorrhoea, but is ineffective against C trachomatis. Of the 54 men given 250 mg ciprofloxacin, six (11%) showed minor abnormalities of liver function tests after treatment.
摘要
单次口服500毫克环丙沙星用于治疗5例淋菌性尿道炎男性患者和5例淋菌性直肠炎男性患者，所有患者均治愈。在随后的一项研究中，环丙沙星剂量减至250毫克，治疗了54例男性的57例淋病感染（47例尿道感染、7例直肠感染和3例咽部感染）；淋病奈瑟菌分离株中有4株是产青霉素酶菌株。所有患者的淋病感染均治愈。9例淋菌性尿道炎男性患者的尿道标本在治疗前检出沙眼衣原体。治疗7天后，所有这些患者以及另外7例治疗前衣原体阴性的男性患者再次分离出这些病原体。结论是，单次口服环丙沙星是治疗单纯性淋病的有效方法，但对沙眼衣原体无效。在接受250毫克环丙沙星治疗的54例男性中，6例（11%）治疗后肝功能检查出现轻微异常。
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