• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

全染色体范围的事件伴随着四倍体细胞中隐性突变的表达。

Chromosome-wide event accompanies the expression of recessive mutations in tetraploid cells.

作者信息

Chasin L A, Urlaub G

出版信息

Science. 1975 Mar 21;187(4181):1091-3. doi: 10.1126/science.1167702.

DOI:10.1126/science.1167702
PMID:1167702
Abstract

Mutants resistant to 6-thioguanine were induced in pseudotetraploid hybrid Chinese hamster cells homozygous wild-type at the locus for hypoxanthine phophoribosyl transferase but heterozygous for the linked marker glucose-6-phosphate dehydrogenase. About half of these mutants had concomitantly lost the wild-type allele for glucose-6-phosphate dehydrogenase, as expected if mutation plus chromosome segregation had occurred.

摘要

在次黄嘌呤磷酸核糖转移酶基因座为纯合野生型，但在连锁标记葡萄糖-6-磷酸脱氢酶基因座为杂合的假四倍体杂种中国仓鼠细胞中，诱导出了对6-硫鸟嘌呤具有抗性的突变体。正如预期的那样，如果发生了突变加染色体分离，这些突变体中约有一半同时失去了葡萄糖-6-磷酸脱氢酶的野生型等位基因。

相似文献

1
Chromosome-wide event accompanies the expression of recessive mutations in tetraploid cells.全染色体范围的事件伴随着四倍体细胞中隐性突变的表达。
Science. 1975 Mar 21;187(4181):1091-3. doi: 10.1126/science.1167702.
2
Isolation of mammalian cell mutants deficient in glucose-6-phosphate dehydrogenase activity: linkage to hypoxanthine phosphoribosyl transferase.缺乏葡萄糖-6-磷酸脱氢酶活性的哺乳动物细胞突变体的分离：与次黄嘌呤磷酸核糖基转移酶的连锁关系
Proc Natl Acad Sci U S A. 1975 Feb;72(2):493-7. doi: 10.1073/pnas.72.2.493.
3
Ploidy level and mutation to hypoxanthine-guanine-phosphoribosyl-transferase (HGPRT) deficiency in Chinese hamster cells.中国仓鼠细胞的倍性水平及次黄嘌呤 - 鸟嘌呤 - 磷酸核糖转移酶（HGPRT）缺陷突变
Mutat Res. 1975 May;28(2):239-50. doi: 10.1016/0027-5107(75)90102-5.
4
The effect of ploidy on chemical mutagenesis in cultured Chinese hamster cells.倍性对培养的中国仓鼠细胞化学诱变的影响。
J Cell Physiol. 1973 Oct;82(2):299-307. doi: 10.1002/jcp.1040820218.
5
Evidence for linkage of 3-phosphoglycerate kinase, hypoxanthine-guanine-phosphoribosyl transferase, and glucose 6-phosphate dehydrogenase loci in Chinese hamster cells studied by using a relationship between gene multiplicity and enzyme activity.利用基因多态性与酶活性之间的关系研究中国仓鼠细胞中3-磷酸甘油酸激酶、次黄嘌呤-鸟嘌呤磷酸核糖转移酶和葡萄糖6-磷酸脱氢酶基因座的连锁证据。
Biochem Genet. 1972 Aug;7(1):33-40. doi: 10.1007/BF00487007.
6
Spontaneous mutation rate to thioguanine resistance is decreased in polyploid hamster cells.多倍体仓鼠细胞对硫鸟嘌呤耐药的自发突变率降低。
J Cell Physiol. 1978 Jul;96(1):81-6. doi: 10.1002/jcp.1040960110.
7
Mutants of cultured chinese hamster cells deficient in adenine phosphoribosyl transferase.缺乏腺嘌呤磷酸核糖转移酶的中国仓鼠培养细胞突变体。
Cell. 1974 May;2(1):43-54. doi: 10.1016/0092-8674(74)90007-5.
8
Linkage of the loci for glucose-6-phosphate dehydrogenase and for inosinic acid pyrophosphorylase to the X chromosome of the field-vole Microtus agrestis.葡萄糖-6-磷酸脱氢酶和肌苷酸焦磷酸化酶基因座与田鼠（Microtus agrestis）X染色体的连锁关系。
J Cell Sci. 1975 Jan;17(1):95-112. doi: 10.1242/jcs.17.1.95.
9
Mutant alleles for hypoxanthine phosphoriboxyltransferase: codominant expression, complementation, and segregation in hybrid Chinese hamster cells.次黄嘌呤磷酸核糖转移酶的突变等位基因：在中国仓鼠杂交细胞中的共显性表达、互补作用和分离现象
Somatic Cell Genet. 1976 Sep;2(5):453-67. doi: 10.1007/BF01542725.
10
Somatic cell hybrids.体细胞杂种
Sov J Dev Biol. 1971 Mar-Apr;2(2):93-110.

引用本文的文献

1
Bioengineering of Antibody Fragments: Challenges and Opportunities.抗体片段的生物工程：挑战与机遇
Bioengineering (Basel). 2023 Jan 17;10(2):122. doi: 10.3390/bioengineering10020122.
2
Recent advances in mammalian protein production.哺乳动物蛋白质生产的最新进展。
FEBS Lett. 2014 Jan 21;588(2):253-60. doi: 10.1016/j.febslet.2013.11.035. Epub 2013 Dec 6.
3
Chromosome segregation is frequently associated with the expression of recessive mutations in mouse cells.染色体分离常常与小鼠细胞中隐性突变的表达相关。
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1768-72. doi: 10.1073/pnas.78.3.1768.
4
Chemical carcinogens transform BHK cells by inducing a recessive mutation.化学致癌物通过诱导隐性突变来转化BHK细胞。
Mol Cell Biol. 1982 Feb;2(2):97-105. doi: 10.1128/mcb.2.2.97-105.1982.
5
Amplification of hypoxanthine-guanine phosphoribosyltransferase genes in chromosome-mediated gene transferents.染色体介导的基因转移体中次黄嘌呤 - 鸟嘌呤磷酸核糖基转移酶基因的扩增
Mol Cell Biol. 1984 Apr;4(4):618-24. doi: 10.1128/mcb.4.4.618-624.1984.
6
Spontaneous fusion in vivo between normal host and tumor cells: possible contribution to tumor progression and metastasis studied with a lectin-resistant mutant tumor.正常宿主细胞与肿瘤细胞在体内的自发融合：利用凝集素抗性突变肿瘤研究其对肿瘤进展和转移的可能作用。
Mol Cell Biol. 1983 Apr;3(4):523-38. doi: 10.1128/mcb.3.4.523-538.1983.
7
Somatic cell fusion as a source of genetic rearrangement leading to metastatic variants.体细胞融合作为导致转移变体的基因重排来源。
Cancer Metastasis Rev. 1984;3(3):193-222. doi: 10.1007/BF00048385.
8
Electrophoretic shift mutants in Chinese hamster ovary cells: evidence for genetic diploidy.中国仓鼠卵巢细胞中的电泳迁移突变体：遗传二倍体的证据。
Proc Natl Acad Sci U S A. 1978 Apr;75(4):1919-23. doi: 10.1073/pnas.75.4.1919.