Clyburn P A, Rosen M
Department of Anaesthetics, University Hospital of Wales, Heath Park, Cardiff.
Anaesthesia. 1988 Mar;43(3):190-3. doi: 10.1111/j.1365-2044.1988.tb05537.x.
Twenty-four patients who underwent elective cholecystectomy received double-blind increments of either pethidine 30 mg or a mixture of pethidine 30 mg and doxapram 45 mg delivered on a patient-controlled basis. A loading dose of doxapram 100 mg or saline was administered. There was no difference in respiratory depression as indicated by respiratory frequency and end tidal carbon dioxide concentration. The incidence of respiratory apnoea was similar in the two groups but apnoea was of shorter duration in patients who received doxapram, although the difference was not significant. Patients who received doxapram assessed overall pain as worse on a linear analogue scale (p less than 0.05) but demanded similar amounts of pethidine. There was no difference in pain on movement.
24例行择期胆囊切除术的患者接受了双盲递增剂量的哌替啶30mg或哌替啶30mg与多沙普仑45mg的混合物，采用患者自控给药方式。给予100mg多沙普仑或生理盐水的负荷剂量。呼吸频率和呼气末二氧化碳浓度显示，两组在呼吸抑制方面无差异。两组呼吸暂停的发生率相似，但接受多沙普仑的患者呼吸暂停持续时间较短，尽管差异不显著。接受多沙普仑的患者在线性模拟量表上对总体疼痛的评估更差（p<0.05），但所需哌替啶的量相似。运动时的疼痛无差异。
