Yamada K, Nishida K, Hibi M, Hirano T, Matsuda Y
Laboratory of Cytogenetics, Division of Bioscience, Graduate School of Environmental Earth Science, Sapporo, Japan.
Cytogenet Cell Genet. 2001;94(1-2):39-42. doi: 10.1159/000048780.
Gab1 and Gab2 are members of the Gab family which act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. We determined chromosome locations of the two genes in human, mouse and rat by fluorescence in situ hybridization. The Gab1 gene was localized to chromosome 4q31.1 in human, 8C3 in mouse and 19q11.1--> q11.2 in rat, and the Gab2 gene was located on chromosome 11q13.4-->q13.5 in human, 7E2 in mouse and 1q33.2-->q33.3 in rat. All human, mouse and rat Gab1 and Gab2 genes were localized to chromosome regions where conserved homology has been identified among the three species.
Gab1和Gab2是Gab家族的成员，作为衔接蛋白，通过细胞因子和生长因子受体以及T细胞和B细胞抗原受体来传递各种刺激信号。我们通过荧光原位杂交确定了这两个基因在人、小鼠和大鼠中的染色体定位。Gab1基因在人中定位于4q31.1染色体，在小鼠中定位于8C3，在大鼠中定位于19q11.1→q11.2；Gab2基因在人中位于11q13.4→q13.5染色体，在小鼠中位于7E2，在大鼠中位于1q33.2→q33.3。所有人类、小鼠和大鼠的Gab1和Gab2基因都定位于在这三个物种中已确定存在保守同源性的染色体区域。
