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1
Effects of 5-bromodeoxyuridine and 5-iododeoxyuridine on a latent herpes simplex virus infection.5-溴脱氧尿苷和5-碘脱氧尿苷对潜伏性单纯疱疹病毒感染的影响。
Antimicrob Agents Chemother. 1975 Jul;8(1):18-21. doi: 10.1128/AAC.8.1.18.
2
In vitro effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5'-amino-5-iodo-2',5'-dideoxyuridine and 2-deoxy-D-glucose on latent ganglionic herpes simplex virus infection.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷、5'-氨基-5-碘-2'，5'-二脱氧尿苷和2-脱氧-D-葡萄糖对潜伏性神经节单纯疱疹病毒感染的体外作用。
Antiviral Res. 1984 Apr;4(1-2):53-61. doi: 10.1016/0166-3542(84)90025-1.
3
Incorporation of idoxuridine analogs into corneal herpes simplex virus.碘苷类似物掺入单纯疱疹性角膜炎病毒中。
Ann Ophthalmol. 1972 Nov;4(11):991-6.
4
(E)-5-(2-bromovinyl)-2'-Deoxyuridine in the treatment of experimental herpes simplex keratitis.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷治疗实验性单纯疱疹性角膜炎
Antimicrob Agents Chemother. 1980 Jan;17(1):8-12. doi: 10.1128/AAC.17.1.8.
5
Use of 5-iodo-2-deoxyuridine (Idoxuridine) in cutaneous herpes simplex.5-碘-2-脱氧尿苷（碘苷）在皮肤单纯疱疹中的应用。
Calif Med. 1965 Oct;103(4):247-8.
6
Efficacy of bromovinyldeoxyuridine in the treatment of herpes simplex virus and varicella-zoster virus eye infections.溴乙烯脱氧尿苷治疗单纯疱疹病毒和水痘带状疱疹病毒眼部感染的疗效
Antiviral Res. 1984 Oct;4(5):281-91. doi: 10.1016/0166-3542(84)90033-0.
7
Topical treatment of cutaneous herpes simplex virus infection in hairless mice with (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.用（E）-5-（2-溴乙烯基）-2'-脱氧尿苷及相关化合物对无毛小鼠皮肤单纯疱疹病毒感染进行局部治疗。
Antimicrob Agents Chemother. 1984 Aug;26(2):155-9. doi: 10.1128/AAC.26.2.155.
8
Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine against different herpes simplex virus strains in cell culture and against experimental herpes encephalitis in mice.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷在细胞培养中对不同单纯疱疹病毒株以及在小鼠实验性疱疹性脑炎中的疗效。
Antiviral Res. 1982 Oct;2(5):255-65. doi: 10.1016/0166-3542(82)90049-3.
9
Comparative evaluation of BVDU ((E)-5-(2-bromovinyl)-2'-deoxyuridine) in the treatment of experimental herpes simplex keratitis in rabbits.BVDU（(E)-5-(2-溴乙烯基)-2'-脱氧尿苷）治疗兔实验性单纯疱疹性角膜炎的比较评价
Bull Soc Belge Ophtalmol. 1979;186:109-18.
10
[UV inactivation of herpes simplex virus from cell cultures treated with 5-bromodeoxyuridine and 5-iododeoxyuridine].
Arch Gesamte Virusforsch. 1969;28(2):203-11.

引用本文的文献

1
Photoinactivation of latent herpes simplex virus in rabbit kidney cells.兔肾细胞中潜伏性单纯疱疹病毒的光灭活
Antimicrob Agents Chemother. 1976 Aug;10(2):229-33. doi: 10.1128/AAC.10.2.229.

本文引用的文献

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Anti-viral activities of several iodinated pyrimidine deoxyribonucleosides.几种碘化嘧啶脱氧核糖核苷的抗病毒活性。
Nature. 1962 Jun 9;194:985-6. doi: 10.1038/194985a0.
2
Clinical cure of herpes simplex keratitis by 5-iodo-2-deoxyuridine.5-碘-2-脱氧尿苷对单纯疱疹性角膜炎的临床治愈作用
Proc Soc Exp Biol Med. 1962 Feb;109:251-2. doi: 10.3181/00379727-109-27169.
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RECENT STUDIES WITH 5-IODODEOXYURIDINE (IUDR) AND RELATED COMPOUNDS.5-碘脱氧尿苷（IUDR）及相关化合物的近期研究。
Exp Cell Res. 1963;24:SUPPL9:479-84. doi: 10.1016/0014-4827(63)90288-x.
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Plaque inhibition test for detection of specific inhibitors of DNA containing viruses.用于检测含DNA病毒特异性抑制剂的噬斑抑制试验。
Proc Soc Exp Biol Med. 1961 May;107:142-5.
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Synthesis and biological activities of iododeoxyuridine, an analog of thymidine.胸腺嘧啶核苷类似物碘脱氧尿苷的合成及生物活性
Biochim Biophys Acta. 1959 Mar;32(1):295-6. doi: 10.1016/0006-3002(59)90597-9.
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Induction of murine C-type viruses from clonal lines of virus-free BALB-3T3 cells.从无病毒的BALB-3T3细胞克隆系中诱导出鼠C型病毒。
Science. 1971 Oct 8;174(4005):157-9. doi: 10.1126/science.174.4005.157.
7
Activation of viruses in human tumors by 5-iododeoxyuridine and dimethyl sulfoxide.5-碘脱氧尿苷和二甲基亚砜对人类肿瘤中病毒的激活作用。
Science. 1972 Jan 14;175(4018):198-9. doi: 10.1126/science.175.4018.198.
8
Activation of Epstein-Barr virus by 5-bromodeoxyuridine in "virus-free" human cells (complement-fixing antigen-immunofluorescence-leukocytes).5-溴脱氧尿苷在“无病毒”人细胞（补体结合抗原-免疫荧光-白细胞）中激活爱泼斯坦-巴尔病毒
Proc Natl Acad Sci U S A. 1972 Jan;69(1):83-5. doi: 10.1073/pnas.69.1.83.
9
Synthesis of Epstein-Barr virus after activation of the viral genome in a "virus-negative" human lymphoblastoid cell (Raji) made resistant to 5-bromodeoxyuridine (thymidine kinase-virus antigen-immunofluorescence-herpesvirus fingerprints).在对5-溴脱氧尿苷产生抗性的“病毒阴性”人淋巴母细胞（拉吉细胞）中激活病毒基因组后，爱泼斯坦-巴尔病毒的合成（胸苷激酶-病毒抗原-免疫荧光-疱疹病毒指纹图谱）
Proc Natl Acad Sci U S A. 1972 Jan;69(1):78-82. doi: 10.1073/pnas.69.1.78.
10
Induction of Epstein-Barr virus-related membrane antigens by 5-iododeoxyuridine in non-producer human lymphoblastoid cells.5-碘脱氧尿苷在非产生性人淋巴母细胞样细胞中诱导爱泼斯坦-巴尔病毒相关膜抗原
Nat New Biol. 1973 Nov 21;246(151):70-2. doi: 10.1038/newbio246070a0.

5-溴脱氧尿苷和5-碘脱氧尿苷对潜伏性单纯疱疹病毒感染的影响。

Effects of 5-bromodeoxyuridine and 5-iododeoxyuridine on a latent herpes simplex virus infection.

作者信息

Varani J, Kelleher J J

出版信息

Antimicrob Agents Chemother. 1975 Jul;8(1):18-21. doi: 10.1128/AAC.8.1.18.

DOI:10.1128/AAC.8.1.18
PMID:1172408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429253/
Abstract

A latent herpes simplex virus infection was established in rabbit kidney cells. Treatment of the cells with 5-bromo-2-deoxyuridine after the latent infection was established had no effect on the rate of virus recovery but did extend the latent period before active virus growth resumed. In contrast to this, treatment of cells with 5-bromo-2-deoxyuridine or 5-iodo-2-deoxyuridine prior to infection with virus increased the subsequent rate of virus recovery.

摘要

在兔肾细胞中建立了单纯疱疹病毒潜伏感染。在潜伏感染建立后用5-溴-2-脱氧尿苷处理细胞，对病毒复苏率没有影响，但确实延长了活跃病毒生长恢复前的潜伏期。与此相反，在病毒感染前用5-溴-2-脱氧尿苷或5-碘-2-脱氧尿苷处理细胞，会提高随后的病毒复苏率。