Berry S D, Seager M A
Department of Psychology and Center for Neuroscience, Miami University, Oxford, Ohio 45056, USA.
Neurobiol Learn Mem. 2001 Nov;76(3):298-313. doi: 10.1006/nlme.2001.4025.
Studies are reviewed that support a hypothesized role for hippocampal theta oscillations in the neural plasticity underlying behavioral learning. Begun in Richard F. Thompson's laboratory in the 1970s, these experiments have documented a relationship between free-running 3- to 7-Hz hippocampal slow waves (theta) and rates of acquisition in rabbit classical nictitating membrane (NM) conditioning. Lesion and drug manipulations of septohippocampal projections have affected NM and jaw movement conditioning in ways consistent with a theta-related brain state being an important modulator of behavioral acquisition. These findings provide essential empirical support for the recently developed neurobiological and computational models that posit an important role for rhythmic oscillations (such as theta) in cellular plasticity and behavioral learning.
本文回顾了一些研究，这些研究支持海马体θ振荡在行为学习背后的神经可塑性中所起的假设作用。这些实验始于20世纪70年代理查德·F·汤普森的实验室，记录了自由运行的3至7赫兹海马体慢波（θ波）与兔子经典瞬膜（NM）条件反射中的习得率之间的关系。对隔海马投射的损伤和药物操作以与θ相关脑状态作为行为习得的重要调节因子相一致的方式影响了NM和下颌运动条件反射。这些发现为最近发展的神经生物学和计算模型提供了重要的实证支持，这些模型认为节律性振荡（如θ波）在细胞可塑性和行为学习中起重要作用。
