Department of Psychology and Center for Neuroscience, Miami University, 90 North Patterson Avenue, Oxford, OH 45056, USA.
Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21371-6. doi: 10.1073/pnas.0908403106. Epub 2009 Nov 25.
The hippocampus and cerebellum are critically involved in trace eyeblink classical conditioning (EBCC). The mechanisms underlying the hippocampal-cerebellar interaction during this task are not well-understood, although hippocampal theta (3-7 Hz) oscillations are known to reflect a favorable state for EBCC. Two groups of rabbits received trace EBCC in which a brain-computer interface administered trials in either the explicit presence or absence of naturally occurring hippocampal theta. A high percentage of robust theta led to a striking enhancement of learning accompanied by rhythmic theta-band (6-7 Hz) oscillations in the interpositus nucleus (IPN) and cerebellar cortex that were time-locked both to hippocampal rhythms and sensory stimuli during training. Rhythmic oscillations were absent in the cerebellum of the non-theta group. These data strongly suggest a beneficial impact of theta-based coordination of hippocampus and cerebellum and, importantly, demonstrate that hippocampal theta oscillations can be used to index, and perhaps modulate, the functional properties of the cerebellum.
海马体和小脑在痕迹眼跳经典条件反射（EBCC）中起着至关重要的作用。尽管已知海马体θ（3-7 Hz）振荡反映了 EBCC 的有利状态，但在这个任务中海马体-小脑相互作用的机制还不是很清楚。两组兔子接受了痕迹 EBCC，其中脑机接口在海马体θ存在或不存在的情况下进行试验。大量的强θ导致学习显著增强，同时在中间核（IPN）和小脑皮层中出现节律性θ波段（6-7 Hz）振荡，这些振荡与训练过程中海马体节律和感觉刺激时间锁定。在没有θ的组的小脑中没有出现节律性振荡。这些数据强烈表明，基于θ的海马体和小脑的协调具有有益的影响，重要的是，证明了海马体θ振荡可以用来标记，也许可以调节，小脑的功能特性。
