Effect of paternal age on human sperm chromosomes.

作者信息

Sartorelli E M, Mazzucatto L F, de Pina-Neto J M

机构信息

Departamento de Biologia Celular, Embriologia e Genética, Centro de Ciĕncias Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.

出版信息

Fertil Steril. 2001 Dec;76(6):1119-23. doi: 10.1016/s0015-0282(01)02894-1.

DOI:10.1016/s0015-0282(01)02894-1

PMID:11730737

Abstract

OBJECTIVE

To investigate whether increased age alters the frequency and type of chromosomal anomalies in human spermatozoa.

DESIGN

Semen specimens were collected from donors via masturbation; cytogenetic studies were performed on sperm chromosomes after heterologous (human-hamster) in vitro fertilization.

SETTING

Cytogenetics Laboratory, Genetics Department, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.

PATIENT(S): Seven men ages 59-74 (older group) and five men ages 23-39 (control group).

MAIN OUTCOME MEASURE(S): Frequency and types of chromosomal anomalies in older and control group donors.

RESULT(S): The frequency of numerical and structural aberrations (acentric fragments and complex radial figures) was significantly greater in chromosomes of older donors when compared with those of the control group.

CONCLUSION(S): The higher frequency of sperm chromosome aberrations in older men was mainly a result of increased nondisjunction, acentric fragments, and complex radial figures.

摘要