蛇床子中具有保肝活性的倍半萜对他克林诱导的Hep G2细胞毒性作用的研究
Sesquiterpenes with hepatoprotective activity from Cnidium monnieri on tacrine-induced cytotoxicity in Hep G2 cells.
作者信息
Oh Hyuncheol, Kim Jung-Sik, Song Eun-Kyoung, Cho Hyun, Kim Do-Hoon, Park Sung-Eun, Lee Ho-Sub, Kim Youn-Chul
机构信息
Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Korea.
出版信息
Planta Med. 2002 Aug;68(8):748-9. doi: 10.1055/s-2002-33796.
Bioassay-guided fractionation of the EtOH extract of Cnidium monnieri (Apiaceae) furnished two hepatoprotective sesquiterpenes, torilin (1) and torilolone (2), together with a new derivative, 1-hydroxytorilin (3). Compounds 1 and 2 showed hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC50 values of compounds 1 and 2 were 20.6 +/- 1.86 (P < 0.01) and 3.6 +/- 0.1 (P < 0.01) microM, respectively. Silybin as a positive control showed an EC50 value of 69.0 +/- 3.4 microM.
对蛇床子（伞形科）乙醇提取物进行生物活性导向分离，得到了两种具有肝保护作用的倍半萜类化合物，蛇床素（1）和蛇床酮（2），以及一种新衍生物，1-羟基蛇床素（3）。化合物1和2对他克林诱导的人肝源性Hep G2细胞毒性具有肝保护作用。化合物1和2的半数有效浓度（EC50）值分别为20.6±1.86（P<0.01）和3.6±0.1（P<0.01）微摩尔。作为阳性对照的水飞蓟宾的EC50值为69.0±3.4微摩尔。
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