Majeed Muhammed, Nagabhushanam Kalyanam, Paulose Shaji, Rajalakshmi H R, Mundkur Lakshmi
Sami-Sabinsa Group Limited, Bengaluru (Bangalore), Karnataka, 560 058, India.
Sabinsa Corporation, East Windsor, NJ, 08520, USA.
Clin Cosmet Investig Dermatol. 2023 Mar 29;16:769-782. doi: 10.2147/CCID.S403418. eCollection 2023.
There has been a growing interest in the use of probiotics and their products for skin care, over the last decade. LactoSporin is the extracellular metabolite of a spore-forming probiotic () MTCC 5856, with antimicrobial and skin protecting activity.
The anti-skin-aging potential of LactoSporin was evaluated in a randomized, double-blinded, placebo-controlled study in healthy female participants (70 screened and 56 randomized). The participants applied either LactoSporin or matched placebo formulation (N=28 in each group) for 10 weeks, and the effects were assessed by dermatological, and non-invasive instrument-based evaluation using Antera, Cutometer, Corneometer, and Tewameter. All the 56 participants completed the study and were included for the analysis.
The regular use of LactoSporin cream for 10 weeks showed a significant reduction in visibility of wrinkles around crow's feet, nasolabial folds, frown lines, and facial fine lines compared to baseline and placebo by dermatological and Antera assessments. LactoSporin showed improvement in skin elasticity and hydration by dermatological assessments, but the effect was not significantly different from placebo when assessed by Cutometer, Corneometer, and Tewameter. No adverse events or skin irritation was observed in any participants during the study.
These results suggest that LactoSporin could be a safe natural ingredient to reduce wrinkles and fine lines in cosmetic formulations.
在过去十年中，益生菌及其产品在皮肤护理中的应用越来越受到关注。LactoSporin是一种产孢益生菌（）MTCC 5856的细胞外代谢产物，具有抗菌和皮肤保护活性。
在一项针对健康女性参与者的随机、双盲、安慰剂对照研究中评估了LactoSporin的抗皮肤衰老潜力（筛选70人，随机分组56人）。参与者使用LactoSporin或匹配的安慰剂配方（每组28人），持续10周，并通过皮肤科检查以及使用Antera、Cutometer、Corneometer和Tewameter进行的非侵入性仪器评估来评估效果。所有56名参与者均完成研究并纳入分析。
与基线和安慰剂相比，通过皮肤科检查和Antera评估，持续10周定期使用LactoSporin乳膏可显著减少鱼尾纹、鼻唇沟、皱眉纹和面部细纹的可见度。通过皮肤科评估，LactoSporin显示皮肤弹性和水分含量有所改善，但通过Cutometer、Corneometer和Tewameter评估时，其效果与安慰剂无显著差异。在研究期间，未观察到任何参与者出现不良事件或皮肤刺激。
这些结果表明，LactoSporin可能是化妆品配方中一种安全的天然成分，可减少皱纹和细纹。
