Soares C N, Cohen L S, Otto M W, Harlow B L
Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA.
J Womens Health Gend Based Med. 2001 Nov;10(9):873-8. doi: 10.1089/152460901753285778.
We examined the characteristics of 33 women with a diagnosis of premenstrual dysphoric disorder (PMDD) who did (n = 19) or did not (n = 14) report a history of major depression. Five hundred thirteen older premenopausal women (ages 36-44) from a community-based sample completed a prospective evaluation of PMDD with daily records. The diagnosis of PMDD was confirmed in 33 women (6.3%), and 14 subjects met criteria for PMDD with no history of depression. Demographic characteristics, cigarette smoking, and menstrual and reproductive history of subjects with PMDD who did or did not report a history of depression were compared. Women with PMDD and no history of depression were more educated and more frequently had a marital disruption (p < 0.05). No significant differences were observed with respect to reproduction-related characteristics or past cigarette smoking. These preliminary data suggest the existence of characteristics particularly related to women who meet criteria for PMDD and have no history of depression. Given the significant psychosocial impairment commonly associated with PMDD symptoms and the existing data that support its classification and adequate treatment as a distinct clinical entity, further studies are needed to better identify predictors of this syndrome unrelated to a lifetime history of depression.
我们研究了33名被诊断为经前烦躁障碍（PMDD）的女性的特征，她们中有19人报告有重度抑郁病史，14人没有。从社区样本中选取了513名年龄较大的绝经前女性（36 - 44岁），她们通过每日记录完成了对PMDD的前瞻性评估。33名女性（6.3%）被确诊为PMDD，其中14名受试者符合PMDD标准且无抑郁病史。对有或无抑郁病史的PMDD受试者的人口统计学特征、吸烟情况以及月经和生殖史进行了比较。无抑郁病史的PMDD女性受教育程度更高，婚姻破裂的情况更常见（p < 0.05）。在生殖相关特征或既往吸烟方面未观察到显著差异。这些初步数据表明，存在一些与符合PMDD标准且无抑郁病史的女性特别相关的特征。鉴于PMDD症状通常会导致显著的心理社会功能损害，且现有数据支持将其作为一种独特的临床实体进行分类和适当治疗，因此需要进一步研究以更好地确定与抑郁终生史无关的该综合征的预测因素。
