Kane R D, Hawkins H K, Miller J A, Noce P S
Cancer. 1975 Oct;36(4):1473-82. doi: 10.1002/1097-0142(197510)36:4<1473::aid-cncr2820360440>3.0.co;2-d.
A syndrome is described in which severe, clinically unexplained dyspnea is found at autopsy to be caused by multiple microscopic tumor emboli. Such a situation was found in 8 of 16 cases of multiple microscopic tumor emboli in the pulmonary arteries without significant lymphatic or parenchymal involvement of the lungs. The origins oftumor emboli included carcinomas of the prostate, breast, stomach, pancreas, and liver. In the 8 cases that presented with unexplained dyspnea, initial physical, roentgenographic, and electrocardiographic examinations were not diagnostic. Clinical or morphological evidence of car pulmonale was pre emboli did not invade the walls of pulmonary vessels but were frequently associated with thrombi. Recognition of this clinicopathologic entity becomes important as progress is made in cancer therapy.
本文描述了一种综合征，在尸检中发现严重的、临床上无法解释的呼吸困难是由多个微小肿瘤栓子引起的。在16例肺动脉多发微小肿瘤栓子且肺部无明显淋巴管或实质受累的病例中，有8例出现了这种情况。肿瘤栓子的来源包括前列腺癌、乳腺癌、胃癌、胰腺癌和肝癌。在出现无法解释的呼吸困难的8例病例中，最初的体格检查、X线检查和心电图检查均无诊断价值。肺心病的临床或形态学证据在栓塞前并不存在，栓子未侵犯肺血管壁，但常与血栓相关。随着癌症治疗的进展，认识这种临床病理实体变得很重要。
