Hudgel D W, Weil J V
Chest. 1975 Oct;68(4):493-7. doi: 10.1378/chest.68.4.493.
Because of the previous finding of an attenuated hypoxic ventilatory drive in a teenager with severe asthma, the ventilatory responses to hypoxia and hypercapnia were examined during remission in 16 patients with the history of severe asthma. Spirometric and body plethysmographic pulmonary functions were normal or nearly normal just prior to ventilatory drive testing. The ventilatory responses to progressive isocapnic hypoxia and to hyperoxic hypercapnia were studied. Both hypoxic and hypercapnic drives were significantly depressed in the asthmatic patients. Factors known to blunt the ventilatory drives were not present in this group of patients. Hence, the etiology of these changes is unclear. In some patients, these depressed respiratory drives might contribute to hypoventilation, to severe hypoxemia, and to respiratory failure during severe asthma.
由于之前在一名重度哮喘青少年患者中发现低氧通气驱动减弱，因此对16例有重度哮喘病史的患者在缓解期进行了低氧和高碳酸血症通气反应检查。在通气驱动测试前，肺活量测定和体容积描记法测定的肺功能正常或接近正常。研究了对渐进性等碳酸血症低氧和高氧性高碳酸血症的通气反应。哮喘患者的低氧和高碳酸血症驱动均显著降低。已知会减弱通气驱动的因素在这组患者中并不存在。因此，这些变化的病因尚不清楚。在一些患者中，这些降低的呼吸驱动可能导致重度哮喘期间的通气不足、严重低氧血症和呼吸衰竭。
