Topcu Gulaçti, Aydogmus Zeynep, Imre Sedat, Gören Ahmet C, Pezzuto John M, Clement Jason A, Kingston David G I
Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey.
J Nat Prod. 2003 Nov;66(11):1505-8. doi: 10.1021/np030176p.
Four new sesquiterpenes, (8R)-8-bromo-10-epi-beta-snyderol (1), (8S)-8-bromo-beta-snyderol (2), 5-bromo-3-(3'-hydroxy-3'-methylpent-4'-enylidene)-2,4,4-trimethylcyclohexanone (3), and the epoxide 4, have been isolated from the chloroform-methanol extract of Laurencia obtusa, together with the three known compounds alpha-snyderol (5), alpha-snyderol acetate (6), and stigmasterol. The structures of the isolated compounds were elucidated through spectroscopic analyses. Compound 1 showed antimalarial activity, with IC(50) values of 2700 and 4000 ng/mL against the D6 and W2 clones of Plasmodium falciparum, respectively.
从钝形凹顶藻的氯仿 - 甲醇提取物中分离出了四种新的倍半萜，即(8R)-8-溴-10-表-β-斯奈德醇(1)、(8S)-8-溴-β-斯奈德醇(2)、5-溴-3-(3'-羟基-3'-甲基戊-4'-亚烯基)-2,4,4-三甲基环己酮(3)以及环氧化物4，同时还分离出了三种已知化合物α-斯奈德醇(5)、α-斯奈德醇乙酸酯(6)和豆甾醇。通过光谱分析阐明了分离出的化合物的结构。化合物1显示出抗疟活性，对恶性疟原虫的D6和W2克隆的IC(50)值分别为2700和4000 ng/mL。
