Tortoli E, Piersimoni C, Kroppenstedt R M, Montoya-Burgos J I, Reischl U, Giacometti A, Emler S
Int J Syst Evol Microbiol. 2001 Nov;51(Pt 6):2007-2012. doi: 10.1099/00207713-51-6-2007.
A novel mycobacterial species is described in this study. The strain was isolated from the cerebrospinal fluid of a severely immunocompromised AIDS patient. It was scotochromogenic and slow-growing. Characteristic features for its differentiation from other mycobacteria are its lipid pattern and the unique gene sequences within the hypervariable regions of the 16S rDNA. The strain shows susceptibility to current antimycobacterial drugs. The pathogenicity of the novel mycobacterium and its clinical significance are not certain, as the neurological symptoms of the patient could also be due to concomitant infection with Cryptococcus neoformans. The name Mycobacterium doricum sp. nov. is proposed for the novel mycobacterium; the type strain is strain FI-13295T (= DSM 44339T = CIP 106867T).
本研究描述了一种新型分枝杆菌。该菌株从一名严重免疫功能低下的艾滋病患者的脑脊液中分离得到。它是暗产色且生长缓慢的。其与其他分枝杆菌鉴别的特征性特点是其脂质模式以及16S rDNA高变区内独特的基因序列。该菌株对目前的抗分枝杆菌药物敏感。由于患者的神经症状也可能归因于新型隐球菌的合并感染，这种新型分枝杆菌的致病性及其临床意义尚不确定。提议将这种新型分枝杆菌命名为多里克分枝杆菌（Mycobacterium doricum sp. nov.）；模式菌株为FI-13295T（= DSM 44339T = CIP 106867T）。
