秋水仙碱对肝细胞中纤维蛋白原转运的抑制作用。
Inhibition by colchicine of fibrinogen translocation in hepatocytes.
作者信息
Feldmann G, Maurice M, Sapin C, Benhamou J P
出版信息
J Cell Biol. 1975 Oct;67(1):237-43. doi: 10.1083/jcb.67.1.237.
Abstract
In the rat, 8 h after intraperitoneal administration of colchicine, fibrinogen (detected by antirat fibrinogen antibodies labeled with peroxidase) accumulated in the lumina of the rough endoplasmic reticulum of the hepatocytes; 16 and 24 h after colchicine administration, fibrinogen was detected, respectively, in the lumina of the smooth endoplasmic reticulum and in the Golgi apparatus. The effect of colchicine on the cytoplasmic translocation of fibrinogen could be due to a direct action of the drug on the membranes of the endoplasmic reticulum or could be the indirect result of the disruptive action of the drug on the microtubules.
摘要
在大鼠中，腹腔注射秋水仙碱8小时后，纤维蛋白原（通过用辣根过氧化物酶标记的抗大鼠纤维蛋白原抗体检测）在肝细胞粗面内质网的管腔中积聚；秋水仙碱给药16小时和24小时后，分别在滑面内质网的管腔和高尔基体中检测到纤维蛋白原。秋水仙碱对纤维蛋白原细胞质转运的影响可能是由于该药物对内质网膜的直接作用，也可能是该药物对微管破坏作用的间接结果。
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