皮肤损伤处白喉棒状杆菌对红霉素和克林霉素的耐药性
Erythromycin and clindamycin resistance in Corynebacterium diphtheriae from skin lesions.
作者信息
Coyle M B, Minshew B H, Bland J A, Hsu P C
出版信息
Antimicrob Agents Chemother. 1979 Oct;16(4):525-7. doi: 10.1128/AAC.16.4.525.
Abstract
Erythromycin- and clindamycin-resistant Corynebacterium diphtheriae isolates were recovered from skin lesions. Resistance to erythromycin and clindamycin was induced by a subinhibitory concentration (0.03 microgram/ml) of erythromycin. Clindamycin (0.07 microgram/ml) was a more effective inducer of its own resistance than of erythromycin resistance. Erythromycin-inducible cross-resistance to vernamycin B alpha was demonstrated in disk diffusion tests.
摘要
从皮肤损伤处分离出了对红霉素和克林霉素耐药的白喉棒状杆菌菌株。亚抑菌浓度（0.03微克/毫升）的红霉素可诱导对红霉素和克林霉素的耐药性。克林霉素（0.07微克/毫升）对自身耐药性的诱导作用比对红霉素耐药性的诱导作用更有效。在纸片扩散试验中证实了红霉素诱导的对维纳霉素Bα的交叉耐药性。
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