Cloarec D, Gouilloud S, Bornet F, Bruley des Varannes S, Bizais Y, Galmiche J P
Groupe Fonctions Digestives et Nutrition, Centre de Recherches sur Volontaires, CHU Nord, Nantes.
Gastroenterol Clin Biol. 1991;15(8-9):588-93.
The prevalence of lactase deficiency (LD) and lactose intolerance is not well known in France. Using breath hydrogen and methane analysis after 50 g oral lactose load, we investigated the prevalences of LD, lactose intolerance, and methane producer status in 102 healthy adults born in western France, and we examined the relationships between these parameters and the daily milk consumption. In 10 subjects with LD and lactose intolerance, we studied the reproducibility of the lactose hydrogen breath test results for the diagnosis of LD and lactose intolerance and estimated the quantity of lactose malabsorbed in comparison with the lactulose hydrogen breath test. The prevalence of LD was 23.4 percent and symptoms of lactose intolerance were observed in 50 percent of the 24 subjects with LD. The daily milk consumption was not significantly different in the 24 subjects with LD and in the 78 subjects without LD (281 +/- 197 vs 303 +/- 217 ml/24 h). The prevalence of methane producer status was 42.1 percent. The symptomatic group of lactose malabsorbers (n = 12) was characterized by a shorter lactose mouth to caecum transit time (39 +/- 20 vs 88 +/- 48 min; P less than 0.05), and more marked hydrogen production (6.1 +/- 2.3 vs 3.4 +/- 2.4 10(3) ppm.min; P less than 0.04). In the 10 subjects with LD and lactose intolerance, the hydrogen breath test was reproducible for diagnosis of LD and lactose intolerance, and for hydrogen production. The quantity of lactose malabsorbed was 60 percent. In France, symptoms of lactose intolerance are not severe and do not affect the daily consumption of milk and dairy products.
乳糖酶缺乏（LD）和乳糖不耐受在法国的流行情况尚不为人所知。通过对50克口服乳糖负荷后进行呼气氢和甲烷分析，我们调查了102名出生于法国西部的健康成年人中LD、乳糖不耐受和甲烷产生者状态的流行情况，并研究了这些参数与每日牛奶摄入量之间的关系。在10名患有LD和乳糖不耐受的受试者中，我们研究了乳糖氢呼气试验结果对LD和乳糖不耐受诊断的可重复性，并与乳果糖氢呼气试验相比估计了乳糖吸收不良的量。LD的患病率为23.4%，在24名患有LD的受试者中，50%观察到乳糖不耐受症状。24名患有LD的受试者与78名未患LD的受试者的每日牛奶摄入量无显著差异（281±197 vs 303±217毫升/24小时）。甲烷产生者状态的患病率为42.1%。乳糖吸收不良的症状组（n = 12）的特点是乳糖从口腔到盲肠的转运时间较短（39±20 vs 88±48分钟；P<0.05），产氢更明显（6.1±2.3 vs 3.4±2.4×10³ ppm·分钟；P<0.04）。在10名患有LD和乳糖不耐受的受试者中，氢呼气试验对LD和乳糖不耐受的诊断以及产氢情况具有可重复性。乳糖吸收不良的量为60%。在法国，乳糖不耐受症状不严重，不影响牛奶和乳制品的日常消费。
