Emre Sinan, Akkin Cezmi, Afrashi Filiz, Yağci Ayşe
Department of Ophthalmology, School of Medicine, Ege University, 351000 Bornova-Izmir, Turkey.
J Cataract Refract Surg. 2002 Jan;28(1):149-51. doi: 10.1016/s0886-3350(01)01029-x.
To measure the changes in corneal thickness with wetting solutions used in ophthalmic surgery.
Ege University, School of Medicine, Department of Ophthalmology, Izmir, Turkey.
Thirty-one adult pigmented rabbits that weighed about 2.5 kg each were anesthetized with pentobarbital sodium. The rabbits were randomly divided into 3 groups to receive 3 wetting solutions: Group 1, Ringer's lactate; Group 2, balanced salt solution (BSS); and Group 3, BSS with glutation (BSS Plus). The solutions were dropped on the right cornea of the rabbits at a rate of 6.0 cc in 12 minutes using an intravenous infusion pump. Corneal thickness was measured by ultrasonic pachymetry before and after the procedure, and the between-group changes in corneal thickness were compared.
The corneal thickness before and after the procedure was 361.27 microm +/- 19.3 (SD) and 380.00 +/- 25.0 microm, respectively, in Group 1 (P =.000); 372.10 +/- 18.8 microm and 388.60 +/- 24.1 microm, respectively, in Group 2 (P =.003); and 358.10 +/- 26.5 microm and 360.10 +/- 24.1 microm, respectively, in Group 3 (P =.316).
As a corneal wetting solution, BSS Plus resulted in significantly fewer changes in corneal thickness than Ringer's lactate or BSS. This should be considered in cases involving long intraocular surgery.
测量眼科手术中使用的湿润溶液对角膜厚度的影响。
土耳其伊兹密尔艾杰大学医学院眼科。
31只成年有色家兔，每只体重约2.5千克，用戊巴比妥钠麻醉。将家兔随机分为3组，分别使用3种湿润溶液：第1组，乳酸林格液；第2组，平衡盐溶液（BSS）；第3组，含谷胱甘肽的BSS（BSS Plus）。使用静脉输液泵以12分钟6.0毫升的速度将溶液滴入家兔右眼角膜。手术前后通过超声测厚法测量角膜厚度，并比较组间角膜厚度的变化。
第1组手术前后角膜厚度分别为361.27微米±19.3（标准差）和380.00±25.0微米（P = 0.000）；第2组分别为372.10±18.8微米和388.60±24.1微米（P = 0.003）；第3组分别为358.10±26.5微米和360.10±24.1微米（P = 0.316）。
作为角膜湿润溶液，BSS Plus导致的角膜厚度变化明显少于乳酸林格液或BSS。在涉及长时间眼内手术的情况下应考虑这一点。
