Rowlands S, Hooper R, Hughes R, Burney P
EPIC, Regeneration House, York Way, UK.
Eur J Neurol. 2002 Jan;9(1):63-7. doi: 10.1046/j.1468-1331.2002.00343.x.
The study consisted of a survey of all new cases of Bell's palsy occurring between 1992 and 1996 in practices contributing data to the UK General Practice Research Database (GPRD). Data were extracted on age, sex, date of episode of Bell's palsy, household number, episodes of herpes simplex, treatment prescribed and referral to relevant hospital departments. A total of 2473 cases of Bell's palsy were identified. The overall incidence for the study period was 20.2 per 100 000 person years of follow-up (95% CI 19.4-21.0). Incidence increased with age. There was no difference in incidence according to sex or season but there were significant changes over time: incidence was higher in the first year of the study period than in subsequent years. There was no clustering of cases in households and no evidence of any tendency for herpes simplex infections to precede Bell's palsy. About 36% of cases were treated with oral steroids and 19% of episodes resulted in hospital referral. In conclusion, Bell's palsy is seen mainly in a primary care setting. The majority of cases are treated expectantly without drugs. Lack of household clustering and lack of a tendency of herpes simplex infections to precede Bell's palsy do not support a viral aetiology.
该研究包括对1992年至1996年间在向英国全科医疗研究数据库(GPRD)提供数据的医疗机构中发生的所有贝尔氏面瘫新病例进行调查。提取了有关年龄、性别、贝尔氏面瘫发作日期、家庭编号、单纯疱疹发作情况、所开处方治疗以及转介至相关医院科室的数据。共识别出2473例贝尔氏面瘫病例。研究期间的总体发病率为每10万人年随访20.2例(95%可信区间19.4 - 21.0)。发病率随年龄增长而增加。发病率在性别或季节方面无差异,但随时间有显著变化:研究期间第一年的发病率高于随后几年。病例在家庭中无聚集现象,也没有证据表明单纯疱疹感染有先于贝尔氏面瘫发生的任何倾向。约36%的病例接受了口服类固醇治疗,19%的发作导致转至医院治疗。总之,贝尔氏面瘫主要见于初级保健机构。大多数病例采用观察等待而不使用药物治疗。缺乏家庭聚集现象以及单纯疱疹感染无先于贝尔氏面瘫发生的倾向不支持病毒病因学。