Stahl B, Thurl S, Henker J, Siegel M, Finke B, Sawatzki G
Numico Research Germany, Friedrichsdorf.
Adv Exp Med Biol. 2001;501:299-306. doi: 10.1007/978-1-4615-1371-1_37.
Oligosaccharides from human milk samples obtained from individual donors were analyzed using high-pH anion-exchange chromatography. Three patterns of neutral oligosaccharides were detected corresponding to milk groups already described. These oligosaccharide groups correspond to the Lewis blood types Le(a-b+), Le(a+b-), and Le(a-b-). A new carbohydrate pattern was detected in a milk sample from a Le(a-b-) person in which only nonfucosylated oligosaccharides and compounds bearing alpha1,3-linked fucosyl residues were found. This finding led to the hypothesis that there exist 4 different oligosaccharide milk groups that fit well to the genetic basis of the Lewis blood group system.
使用高pH值阴离子交换色谱法分析了从个体捐赠者获得的人乳样本中的寡糖。检测到三种中性寡糖模式，对应于已描述的乳类。这些寡糖组对应于Lewis血型Le(a-b+)、Le(a+b-)和Le(a-b-)。在一名Le(a-b-)个体的乳样中检测到一种新的碳水化合物模式，其中仅发现了非岩藻糖基化寡糖和带有α1,3-连接岩藻糖基残基的化合物。这一发现导致了这样一种假设，即存在4种不同的寡糖乳类，它们与Lewis血型系统的遗传基础非常契合。
