Senior B A, Khan M, Schwimmer C, Rosenthal L, Benninger M
Department of Otolaryngology/Head and Neck Surgery, Henry Ford Hospital, Detroit, Michigan, USA.
Laryngoscope. 2001 Dec;111(12):2144-6. doi: 10.1097/00005537-200112000-00012.
To determine the extent to which gastroesophageal reflux (GER)-initiated laryngeal chemoreflexes contribute to obstructive sleep apnea (OSA).
Prospective, nonrandomized clinical trial of an antireflux treatment protocol as a means of reducing the severity of OSA. Population consisted of 10 males aged 20 to 64 years with confirmed OSA (by overnight polysomnography) and GER (by ambulatory pH probe monitoring). Patients were treated with omeprazole and standard antireflux protocol for 30 days and pre- and posttreatment polysomnography variables were compared.
Mean apnea index declined 31% (45-31, P = .04); mean respiratory disturbance index declined 25% (62-46, P = .06). Three patients (30%) are "treatment responders" as defined by traditional OSA treatment definitions.
These results suggest a potential relationship between OSA and GER, the treatment of which may be an effective adjunctive in those with both disorders. Treatment of GER may significantly impact OSA in select individuals.
确定胃食管反流（GER）引发的喉化学反射在多大程度上导致阻塞性睡眠呼吸暂停（OSA）。
一项前瞻性、非随机临床试验，采用抗反流治疗方案作为降低OSA严重程度的一种手段。研究对象为10名年龄在20至64岁之间的男性，确诊为OSA（通过夜间多导睡眠图）和GER（通过动态pH探头监测）。患者接受奥美拉唑和标准抗反流方案治疗30天，并比较治疗前后多导睡眠图变量。
平均呼吸暂停指数下降31%（45 - 31，P = .04）；平均呼吸紊乱指数下降25%（62 - 46，P = .06）。按照传统OSA治疗定义，3名患者（30%）为“治疗反应者”。
这些结果表明OSA与GER之间存在潜在关系，对二者同时存在的患者，GER的治疗可能是一种有效的辅助治疗方法。GER的治疗可能会对部分个体的OSA产生显著影响。
