Higgins H P, Hershman J M, Kenimer J G, Patillo R A, Bayley T A, Walfish P
Ann Intern Med. 1975 Sep;83(3):307-11. doi: 10.7326/0003-4819-83-3-307.
In 14 women with hydatidiform mole, 9 were hyperthyroid. Serum thyroxine (T4) levels varied between 18 and 34 mug/100 ml, and serum triiodothyronine (T3) levels between 300 and 800 ng/100 ml in the hyperthyroid patients. Bioassayable thyroid-stimulating hormone (molar TSH) was found in high concentrations in the serum of 13 patients in whom preoperative serum was available. There was a close correlation between the serum levels of human chorionic gonadotrophin, molar TSH, and T3. Intravenous sodium iodide caused a fall in serum T3 and, to a lesser extent, in T4 in hyperthyroid patients but not in a euthyroid patient. Removal of molar tissue caused a dramatic fall in the serum levels of T3, T4, molar TSH, and human chorionic gonadotrophin. The close correlation between the serum concentrations of molar TSH and human chorionic gonadotrophin lend support to the suggestion that the human chorionic gonadotrophin molecule itself, when present in large amounts, stimulates thyroid function significantly.
在14例葡萄胎患者中，9例有甲状腺功能亢进。甲状腺功能亢进患者的血清甲状腺素（T4）水平在18至34μg/100ml之间，血清三碘甲状腺原氨酸（T3）水平在300至800ng/100ml之间。在可获得术前血清的13例患者的血清中发现了高浓度的生物活性促甲状腺激素（摩尔促甲状腺激素）。血清人绒毛膜促性腺激素、摩尔促甲状腺激素和T3水平之间存在密切相关性。静脉注射碘化钠可使甲状腺功能亢进患者的血清T3水平下降，T4水平也有一定程度下降，但对甲状腺功能正常的患者无此作用。切除葡萄胎组织可使血清T3、T4、摩尔促甲状腺激素和人绒毛膜促性腺激素水平显著下降。摩尔促甲状腺激素和人绒毛膜促性腺激素血清浓度之间的密切相关性支持了这样一种观点，即大量存在的人绒毛膜促性腺激素分子本身可显著刺激甲状腺功能。
