Velkov V V
Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow region, 142290, Russia.
J Biosci. 2001 Dec;26(5):667-83. doi: 10.1007/BF02704764.
This article is focused on the problems of reduction of the risk associated with the deliberate release of genetically modified microorganisms (GMMs) into the environment. Special attention is given to overview the most probable physiological and genetic processes which could be induced in the released GMMs by adverse environmental conditions, namely: (i) activation of quorum sensing and the functions associated with it, (ii) entering into a state of general resistance, (iii) activation of adaptive mutagenesis, adaptive amplifications and transpositions and (iv) stimulation of inter-species gene transfer. To reduce the risks associated with GMMs, the inactivation of their key genes responsible for stress-stimulated increase of viability and evolvability is proposed.
本文聚焦于降低与向环境中故意释放转基因微生物（GMMs）相关风险的问题。特别关注概述最有可能在释放的转基因微生物中由不利环境条件诱导的生理和遗传过程，即：（i）群体感应及其相关功能的激活，（ii）进入一般抗性状态，（iii）适应性诱变、适应性扩增和转座的激活，以及（iv）种间基因转移的刺激。为降低与转基因微生物相关的风险，建议使其负责应激刺激下生存能力和进化能力增加的关键基因失活。
