谷胱甘肽S-转移酶M1基因多态性与老年性白内障易感性的关系
[Relationship between GSTM1 genotype and susceptibility to senile cataract].
作者信息
Hao Y, He S, Gu Z, Zhao Y, Li X, Wang C, Li Q, Liu T
机构信息
Department of Ophthalmology, General Hospital of the PLA, Beijing 100853.
出版信息
Zhonghua Yan Ke Za Zhi. 1999 Mar;35(2):104-6.
OBJECTIVE
To study the relationship between the glutathione s-transferase gene deletion and cataract formation.
METHODS
Blood cells of total of 77 cases with senile cataract and 76 controls were detected for GSTM1 gene, and the subcapsular epithelial cells of 22 cataract lenses were also detected for GSTM1 gene.
RESULTS
The GSTM1 gene deletion rate in cataract group was 53.25% and that in the control group was 46.05%, they being not significantly different statistically (chi(2) = 0.750, P > 0.05, OR = 0.75). GSTM1 gene deletion rate in the subcapsular epithelial cells of 20 cases was basically consistent with that in blood cells.
CONCLUSION
GSTM1 gene deletion is not related to senile cataract formation.
目的
研究谷胱甘肽S-转移酶基因缺失与白内障形成之间的关系。
方法
对77例老年性白内障患者和76例对照者的血细胞进行谷胱甘肽S-转移酶M1（GSTM1）基因检测，同时对22例白内障晶状体的囊下上皮细胞进行GSTM1基因检测。
结果
白内障组GSTM1基因缺失率为53.25%，对照组为46.05%，两组差异无统计学意义（χ² = 0.750，P > 0.05，比值比（OR） = 0.75）。20例患者晶状体囊下上皮细胞的GSTM1基因缺失率与血细胞基本一致。
结论
GSTM1基因缺失与老年性白内障形成无关。
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