Rööst Mattias, Nilsson Peter
Avdelningen för medicin, Universitetssjukhuset MAS, Malmö.
Lakartidningen. 2002 Jan 17;99(3):154-7.
A large proportion of the adult population complains over difficulties in falling asleep, difficulties in maintaining sleep, or early awakening. Despite the fact that sleep disorders may be secondary symptoms to established or subclinical disease processes, more and more evidence has now accumulated to support the notion that sleep disorders may also play a primary role in the pathophysiology of cardiovascular disease. This has recently been documented in association with metabolic disturbances and impaired insulin action following experimental sleep deprivation. Sleep disorders may finally prove to be part of the pathophysiological chain linking adverse psychosocial stress with the metabolic syndrome, and ultimately premature ageing and early mortality.
很大一部分成年人口抱怨入睡困难、难以维持睡眠或早醒。尽管睡眠障碍可能是已确诊或亚临床疾病过程的次要症状,但现在越来越多的证据支持这样一种观点,即睡眠障碍在心血管疾病的病理生理学中也可能起主要作用。最近的文献记载,这与实验性睡眠剥夺后的代谢紊乱和胰岛素作用受损有关。睡眠障碍最终可能被证明是将不良心理社会压力与代谢综合征联系起来的病理生理链的一部分,并最终导致过早衰老和过早死亡。