Elithorn A, Lunzer M, Weinman J
J Neurol Neurosurg Psychiatry. 1975 Aug;38(8):794-8. doi: 10.1136/jnnp.38.8.794.
A battery of computer-based psychological tests given to seven patients with chronic hepatic encephalopathy showed them to be intellectually impaired, particularly on speed-based measures, as compared with general hospital patients and with patients with cirrhosis but without clinical or electroencephalographic evidence of encephalopathy. Two of the seven patients in the latter group also showed evidence of cognitive impairment on some tests. The effects of levodopa were also evaluated by sequential assessment with these tests. Although there was some improvement in speed of performance on certain tasks and a suggestion of deterioration on other measures, there was little overall change. It is concluded that levodopa has an 'arousing' or antidepressant action and that its effect on intellectual functions is secondary to this alerting effect and is consequently dependent on the emotional and attentional status of the patient.
对七名慢性肝性脑病患者进行了一系列基于计算机的心理测试，结果显示与综合医院患者以及患有肝硬化但无脑病临床或脑电图证据的患者相比，这些患者存在智力障碍，尤其是在基于速度的测试中。后一组中的七名患者中有两名在某些测试中也显示出认知障碍的迹象。还通过这些测试的连续评估来评估左旋多巴的效果。尽管在某些任务上表现速度有一些改善，而在其他测试中则有恶化的迹象，但总体变化不大。得出的结论是，左旋多巴具有“唤醒”或抗抑郁作用，其对智力功能的影响继发于这种警觉作用，因此取决于患者的情绪和注意力状态。
