高危人群食管鳞状细胞癌中的人乳头瘤病毒
Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population.
作者信息
Farhadi Mohammad, Tahmasebi Zahra, Merat Shahin, Kamangar Farin, Nasrollahzadeh Dariush, Malekzadeh Reza
机构信息
Digestive Disease Research Center, Shariati Hospital, North Kargar Avenue, Tehran 14114, Iran.
出版信息
World J Gastroenterol. 2005 Feb 28;11(8):1200-3. doi: 10.3748/wjg.v11.i8.1200.
AIM
To investigate the relation of human papillomavirus (HPV) and esophageal squamous cell carcinoma (ESCC) in Iranian patients as compared to normal controls.
METHODS
Using MY09/MY11 consensus primers, we compared the prevalence of a HPV L1 gene in tumor tissues from 38 ESCC cases and biopsied tissues from 38 endoscopically normal Iranian individuals. We also compared the presence of HPV16 and HPV18 in the same samples using type-specific E6/E7 primers.
RESULTS
Fourteen (36.8%) of the 38 ESCC samples but only 5 (13.2%) of the 38 control samples were positive for the HPV L1 gene (P = 0.02). Five (13.2%) of the ESCC samples but none of the control samples were positive for the HPV16 E6/E7 gene (P = 0.05). Three (7.9%) of the ESCC samples and 5 (13.2%) of the control samples were positive for the HPV18 E6/E7 gene (P = 0.71).
CONCLUSION
Our data are consistent with HPV DNA studies conducted in other high-risk areas for ESCC. HPV should be considered as a potential factor contributing to the high incidence of ESCC in Iran and other high-incidence areas of the world.
目的
与正常对照组相比，研究伊朗患者中人类乳头瘤病毒（HPV）与食管鳞状细胞癌（ESCC）的关系。
方法
使用MY09/MY11共识引物，我们比较了38例ESCC病例的肿瘤组织和38例内镜检查正常的伊朗个体的活检组织中HPV L1基因的流行情况。我们还使用型特异性E6/E7引物比较了相同样本中HPV16和HPV18的存在情况。
结果
38例ESCC样本中有14例（36.8%）HPV L1基因呈阳性，但38例对照样本中只有5例（13.2%）呈阳性（P = 0.02）。ESCC样本中有5例（13.2%）HPV16 E6/E7基因呈阳性，但对照样本中无一例呈阳性（P = 0.05）。ESCC样本中有3例（7.9%）HPV18 E6/E7基因呈阳性，对照样本中有5例（13.2%）呈阳性（P = 0.71）。
结论
我们的数据与在其他ESCC高危地区进行的HPV DNA研究一致。HPV应被视为导致伊朗和世界其他高发病地区ESCC高发病率的一个潜在因素。
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