Dahlöf Pia, Norlin-Bagge Eva, Hedner Jan, Ejnell Hasse, Hetta Jerker, Hällström Tore
Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgrenska University Hospital/S, Göteborg, Sweden.
Acta Otolaryngol. 2002 Jan;122(1):86-91. doi: 10.1080/00016480252775797.
Obstructive sleep apnea syndrome (OSAS) is characterized by snoring and apnea during sleep leading to decreased oxygen saturation and disturbed sleep, excessive daytime sleepiness and neuropsychological disturbances. This study investigates cognitive neuropsychological abilities in a group of 53 OSAS patients before and after treatment with uvulopalatopharyngoplasty. General intellectual ability, verbal learning and memory as well as executive functioning were measured at baseline and 6 months postoperatively. After surgery there were significant improvements in verbal learning and memory (mean change -39, SD 57.3, p < 0.001), recall (mean change -24.3, SD 39.3, p < 0.001) and executive functioning (as assessed by percentage of errors on the Wisconsin Card Sorting Test; mean change -9.1, SD 15.7, p < 0.001). These improvements were in accordance with improvements in the degree of sleep apnea, the oxygen desaturation index (mean change -9.7, SD 15.9, p < 0.001) and arterial minimum oxygen saturation (mean change 4.5%, SD 10.2%, p < 0.01). Surgical treatment seems to improve verbal learning, memory and recall and executive functions in parallel with better oxygenation in OSAS.
阻塞性睡眠呼吸暂停综合征（OSAS）的特征是睡眠期间打鼾和呼吸暂停，导致血氧饱和度下降、睡眠紊乱、日间过度嗜睡和神经心理障碍。本研究调查了53例OSAS患者在接受悬雍垂腭咽成形术治疗前后的认知神经心理能力。在基线和术后6个月测量了一般智力能力、言语学习和记忆以及执行功能。手术后，言语学习和记忆（平均变化-39，标准差57.3，p<0.001）、回忆（平均变化-24.3，标准差39.3，p<0.001）和执行功能（通过威斯康星卡片分类测试的错误百分比评估；平均变化-9.1，标准差15.7，p<0.001）有显著改善。这些改善与睡眠呼吸暂停程度、氧饱和度下降指数（平均变化-9.7，标准差15.9，p<0.001）和动脉最低血氧饱和度（平均变化4.5%，标准差10.2%，p<0.01）的改善一致。手术治疗似乎在改善OSAS患者的言语学习、记忆、回忆和执行功能的同时，也改善了氧合情况。
